MTMR3

Myotubularin related protein 3
Identifiers
Symbols	MTMR3 ; FYVE-DSP1; ZFYVE10
External IDs	OMIM: 603558 MGI: 1921552 HomoloGene: 23662 GeneCards: MTMR3 Gene
EC number	3.1.3.48, 3.1.3.64, 3.1.3.95
Gene ontology Molecular function • phosphatidylinositol-3-phosphatase activity • protein serine/threonine phosphatase activity • protein tyrosine phosphatase activity • metal ion binding • phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity Cellular component • nucleoplasm • cytoplasm • cytosol • membrane • extrinsic component of membrane Biological process • protein dephosphorylation • phospholipid metabolic process • phosphatidylinositol biosynthetic process • peptidyl-tyrosine dephosphorylation • small molecule metabolic process • phosphatidylinositol dephosphorylation • negative regulation of autophagosome assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8897	74302
Ensembl	ENSG00000100330	ENSMUSG00000034354
UniProt	Q13615	Q8K296
RefSeq (mRNA)	NM_001013676	NM_028860
RefSeq (protein)	NP_066576	NP_083136
Location (UCSC)	Chr 22: 29.88 – 30.03 Mb	Chr 11: 4.48 – 4.59 Mb
PubMed search

Myotubularin-related protein 3 is a protein that in humans is encoded by the MTMR3 gene.^[1][2][3]

This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene.^[3]

References

1. Laporte J, Hu LJ, Kretz C, Mandel JL, Kioschis P, Coy JF, Klauck SM, Poustka A, Dahl N (Jul 1996). "A gene mutated in X-linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast". Nat Genet 13 (2): 175–82. doi:10.1038/ng0696-175. PMID 8640223.
2. Laporte J, Blondeau F, Buj-Bello A, Tentler D, Kretz C, Dahl N, Mandel JL (Dec 1998). "Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human". Hum Mol Genet 7 (11): 1703–12. doi:10.1093/hmg/7.11.1703. PMID 9736772.
3. "Entrez Gene: MTMR3 myotubularin related protein 3".