DUSP19

Dual specificity phosphatase 19
Mitogen-activated Protein Kinase Phosphatase, SKRP1. PDB 3s4e[1]
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3S4E​
Identifiers
Symbols	DUSP19 ; DUSP17; LMWDSP3; SKRP1; TS-DSP1
External IDs	OMIM: 611437 MGI: 1915332 HomoloGene: 41565 GeneCards: DUSP19 Gene
EC number	3.1.3.16, 3.1.3.48
Gene ontology Molecular function • protein tyrosine phosphatase activity • protein kinase inhibitor activity • MAP-kinase scaffold activity • protein binding • protein tyrosine/threonine phosphatase activity • JUN kinase phosphatase activity • protein kinase activator activity • mitogen-activated protein kinase kinase kinase binding Cellular component • cytoplasm Biological process • inactivation of MAPK activity • negative regulation of protein kinase activity • protein dephosphorylation • JNK cascade • activation of protein kinase activity • peptidyl-tyrosine dephosphorylation • positive regulation of MAPK cascade • positive regulation of JUN kinase activity • negative regulation of JUN kinase activity • positive regulation of protein kinase activity • negative regulation of JNK cascade • positive regulation of JNK cascade • negative regulation of cyclin-dependent protein kinase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	142679	68082
Ensembl	ENSG00000162999	ENSMUSG00000027001
UniProt	Q8WTR2	n/a
RefSeq (mRNA)	NM_001142314	NM_024438
RefSeq (protein)	NP_001135786	NP_077758
Location (UCSC)	Chr 2: 183.08 – 183.1 Mb	Chr 2: 80.62 – 80.63 Mb
PubMed search

Dual specificity protein phosphatase 19 is an enzyme that in humans is encoded by the DUSP19 gene.^[2]

Interactions

DUSP19 has been shown to interact with ASK1^[3] and MAP2K7.^[3][4]

References

1. Wei, C. H.; Ryu, S. Y.; Jeon, Y. H.; Yoon, M. Y.; Jeong, D. G.; Kim, S. J.; Ryu, S. E. (2011). "Crystal structure of a novel mitogen-activated protein kinase phosphatase, SKRP1". Proteins: Structure, Function, and Bioinformatics 79 (11): 3242–3246. doi:10.1002/prot.23156. PMID 21989941.
2. "Entrez Gene: DUSP19 dual specificity phosphatase 19".
3. Zama, Takeru; Aoki Ryoko; Kamimoto Takahiro; Inoue Koichi; Ikeda Yasuo; Hagiwara Masatoshi (Jun 2002). "Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway". J. Biol. Chem. (United States) 277 (26): 23919–26. doi:10.1074/jbc.M200838200. ISSN 0021-9258. PMID 11959862.
4. Zama, Takeru; Aoki Ryoko; Kamimoto Takahiro; Inoue Koichi; Ikeda Yasuo; Hagiwara Masatoshi (Jun 2002). "A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway". J. Biol. Chem. (United States) 277 (26): 23909–18. doi:10.1074/jbc.M200837200. ISSN 0021-9258. PMID 11959861.

Further reading

• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Cheng H, Gao Q, Jiang M, et al. (2003). "Molecular cloning and characterization of a novel human protein phosphatase, LMW-DSP3". Int. J. Biochem. Cell Biol. 35 (2): 226–34. doi:10.1016/S1357-2725(02)00127-9. PMID 12479873.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zama T, Aoki R, Kamimoto T, et al. (2002). "Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway". J. Biol. Chem. 277 (26): 23919–26. doi:10.1074/jbc.M200838200. PMID 11959862.
• Zama T, Aoki R, Kamimoto T, et al. (2002). "A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway". J. Biol. Chem. 277 (26): 23909–18. doi:10.1074/jbc.M200837200. PMID 11959861.