DUSP18

Dual specificity phosphatase 18
PDB rendering based on 2esb.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2ESB​
Identifiers
Symbols	DUSP18 ; DSP18; DUSP20; LMWDSP20
External IDs	OMIM: 611446 MGI: 1922469 HomoloGene: 34984 GeneCards: DUSP18 Gene
EC number	3.1.3.16, 3.1.3.48
Gene ontology Molecular function • protein tyrosine phosphatase activity • protein tyrosine/serine/threonine phosphatase activity • MAP kinase tyrosine/serine/threonine phosphatase activity Cellular component • nucleus • nucleoplasm • cytoplasm • mitochondrial intermembrane space • extrinsic component of mitochondrial inner membrane Biological process • inactivation of MAPK activity • peptidyl-tyrosine dephosphorylation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	150290	75219
Ensembl	ENSG00000167065	ENSMUSG00000047205
UniProt	Q8NEJ0	Q8VE01
RefSeq (mRNA)	NM_001304794	NM_173745
RefSeq (protein)	NP_001291723	NP_776106
Location (UCSC)	Chr 22: 30.65 – 30.67 Mb	Chr 11: 3.9 – 3.9 Mb
PubMed search

Dual specificity protein phosphatase 18 is an enzyme that in humans is encoded by the DUSP18 gene.^[1][2]

References

1. Hood KL, Tobin JF, Yoon C (Oct 2002). "Identification and characterization of two novel low-molecular-weight dual specificity phosphatases". Biochem Biophys Res Commun 298 (4): 545–51. doi:10.1016/S0006-291X(02)02488-9. PMID 12408986.
2. "Entrez Gene: DUSP18 dual specificity phosphatase 18".

Further reading

• Wu Q, Huang S, Sun Y; et al. (2006). "Dual specificity phosphotase 18, interacting with SAPK, dephosphorylates SAPK and inhibits SAPK/JNK signal pathway in vivo.". Front. Biosci. 11: 2714–24. doi:10.2741/2001. PMID 16720344.
• Jeong DG, Cho YH, Yoon TS; et al. (2006). "Structure of human DSP18, a member of the dual-specificity protein tyrosine phosphatase family.". Acta Crystallogr. D Biol. Crystallogr. 62 (Pt 6): 582–8. doi:10.1107/S0907444906010109. PMID 16699184.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Collins JE, Wright CL, Edwards CA; et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Wu Q, Gu S, Dai J; et al. (2003). "Molecular cloning and characterization of a novel dual-specificity phosphatase18 gene from human fetal brain". Biochim. Biophys. Acta 1625 (3): 296–304. doi:10.1016/s0167-4781(02)00629-2. PMID 12591617.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.