PTPN23

Protein tyrosine phosphatase, non-receptor type 23
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3RAU​
Identifiers
Symbols	PTPN23 ; HD-PTP; HDPTP; PTP-TD14
External IDs	OMIM: 606584 MGI: 2144837 HomoloGene: 135706 GeneCards: PTPN23 Gene
EC number	3.1.3.48
Gene ontology Molecular function • protein tyrosine phosphatase activity • protein binding • protein kinase binding Cellular component • nucleus • nucleoplasm • cytoplasm • endosome • early endosome • cytoplasmic membrane-bounded vesicle • ciliary basal body • extracellular exosome Biological process • negative regulation of epithelial cell migration • protein transport • peptidyl-tyrosine dephosphorylation • ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway • cilium morphogenesis • positive regulation of homophilic cell adhesion • positive regulation of adherens junction organization • positive regulation of early endosome to late endosome transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	25930	104831
Ensembl	ENSG00000076201	ENSMUSG00000036057
UniProt	Q9H3S7	Q6PB44
RefSeq (mRNA)	NM_001304482	NM_001081043
RefSeq (protein)	NP_001291411	NP_001074512
Location (UCSC)	Chr 3: 47.38 – 47.41 Mb	Chr 9: 110.39 – 110.41 Mb
PubMed search

Tyrosine-protein phosphatase non-receptor type 23 is an enzyme that in humans is encoded by the PTPN23 gene.^[1][2]

References

1. Toyooka S, Ouchida M, Jitsumori Y, Tsukuda K, Sakai A, Nakamura A, Shimizu N, Shimizu K (Dec 2000). "HD-PTP: A novel protein tyrosine phosphatase gene on human chromosome 3p21.3". Biochem Biophys Res Commun 278 (3): 671–8. doi:10.1006/bbrc.2000.3870. PMID 11095967.
2. "Entrez Gene: PTPN23 protein tyrosine phosphatase, non-receptor type 23".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Mariotti M, Castiglioni S, Maier JA (2006). "Expression analysis and modulation by HIV-Tat of the tyrosine phosphatase HD-PTP". J. Cell. Biochem. 98 (2): 301–8. doi:10.1002/jcb.20770. PMID 16408268.
• Mariotti M, Castiglioni S, Beguinot L, Maier JA (2006). "The tyrosine phosphatase HD-PTP is regulated by FGF-2 through proteasome degradation". Front. Biosci. 11: 2138–43. doi:10.2741/1956. PMID 16720300.
• Castiglioni S, Maier JA, Mariotti M (2007). "The tyrosine phosphatase HD-PTP: A novel player in endothelial migration". Biochem. Biophys. Res. Commun. 364 (3): 534–9. doi:10.1016/j.bbrc.2007.10.022. PMID 17959146.