DUSP15

Dual specificity phosphatase 15
PDB rendering based on 1yz4.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1YZ4​
Identifiers
Symbols	DUSP15 ; VHY
External IDs	MGI: 1934928 HomoloGene: 33586 GeneCards: DUSP15 Gene
EC number	3.1.3.16, 3.1.3.48
Gene ontology Molecular function • protein tyrosine phosphatase activity • protein binding • protein tyrosine/serine/threonine phosphatase activity Cellular component • cytoplasm • plasma membrane Biological process • protein dephosphorylation • transforming growth factor beta receptor signaling pathway • peptidyl-tyrosine dephosphorylation • regulation of cell proliferation • positive regulation of JNK cascade Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	128853	252864
Ensembl	ENSG00000149599	ENSMUSG00000042662
UniProt	Q9H1R2	Q8R4V2
RefSeq (mRNA)	NM_001012644	NM_001159376
RefSeq (protein)	NP_001012662	NP_001152848
Location (UCSC)	Chr 20: 31.85 – 31.87 Mb	Chr 2: 152.94 – 152.95 Mb
PubMed search

Dual specificity protein phosphatase 15 is an enzyme that in humans is encoded by the DUSP15 gene.^[1][2]

The protein encoded by this gene belongs to the non-receptor class of the protein-tyrosine phosphatase family. The encoded protein has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. Three transcript variants, encoding two different isoforms have been found for this gene.^[2]

References

1. Alonso A, Narisawa S, Bogetz J, Tautz L, Hadzic R, Huynh H, Williams S, Gjorloff-Wingren A, Bremer MC, Holsinger LJ, Millan JL, Mustelin T (Jul 2004). "VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX". J Biol Chem 279 (31): 32586–91. doi:10.1074/jbc.M403442200. PMID 15138252.
2. "Entrez Gene: DUSP15 dual specificity phosphatase 15".

Further reading

• Yoon TS, Jeong DG, Kim JH; et al. (2006). "Crystal structure of the catalytic domain of human VHY, a dual-specificity protein phosphatase.". Proteins 61 (3): 694–7. doi:10.1002/prot.20642. PMID 16170801.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.