DUSP22

Dual specificity phosphatase 22
PDB rendering based on 1wrm.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1WRM​, 4WOH​
Identifiers
Symbols	DUSP22 ; JKAP; JSP-1; JSP1; LMW-DSP2; LMWDSP2; MKP-x; MKPX; VHX
External IDs	MGI: 1915926 HomoloGene: 86039 ChEMBL: 3924 GeneCards: DUSP22 Gene
EC number	3.1.3.16, 3.1.3.48
Gene ontology Molecular function • protein tyrosine phosphatase activity • protein tyrosine/serine/threonine phosphatase activity Cellular component • nucleus • cytoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • inactivation of MAPK activity • negative regulation of T cell mediated immunity • protein dephosphorylation • apoptotic process • transforming growth factor beta receptor signaling pathway • multicellular organismal development • cell proliferation • peptidyl-tyrosine dephosphorylation • regulation of cell proliferation • positive regulation of JNK cascade • negative regulation of T cell receptor signaling pathway • negative regulation of T cell activation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	56940	105352
Ensembl	ENSG00000112679	ENSMUSG00000069255
UniProt	Q9NRW4	Q99N11
RefSeq (mRNA)	NM_001286555	NM_001037955
RefSeq (protein)	NP_001273484	NP_001033044
Location (UCSC)	Chr 6: 0.29 – 0.35 Mb	Chr 13: 30.66 – 30.71 Mb
PubMed search

Dual specificity protein phosphatase 22 is an enzyme that in humans is encoded by the DUSP22 gene.^[1][2][3]

Interactions

DUSP22 has been shown to interact with MAPK1^[4] and MAPK8.^[4]

References

1. Smith A, Price C, Cullen M, Muda M, King A, Ozanne B, Arkinstall S, Ashworth A (Sep 1997). "Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7)". Genomics 42 (3): 524–7. doi:10.1006/geno.1997.4756. PMID 9205128.
2. Shen Y, Luche R, Wei B, Gordon ML, Diltz CD, Tonks NK (Nov 2001). "Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1". Proc Natl Acad Sci U S A 98 (24): 13613–8. doi:10.1073/pnas.231499098. PMC 61089. PMID 11717427.
3. "Entrez Gene: DUSP22 dual specificity phosphatase 22".
4. Aoyama, K; Nagata M; Oshima K; Matsuda T; Aoki N (Jul 2001). "Molecular cloning and characterization of a novel dual specificity phosphatase, LMW-DSP2, that lacks the cdc25 homology domain". J. Biol. Chem. (United States) 276 (29): 27575–83. doi:10.1074/jbc.M100408200. ISSN 0021-9258. PMID 11346645.

Further reading

• Aoyama K, Nagata M, Oshima K; et al. (2001). "Molecular cloning and characterization of a novel dual specificity phosphatase, LMW-DSP2, that lacks the cdc25 homology domain.". J. Biol. Chem. 276 (29): 27575–83. doi:10.1074/jbc.M100408200. PMID 11346645.
• Alonso A, Merlo JJ, Na S; et al. (2002). "Inhibition of T cell antigen receptor signaling by VHR-related MKPX (VHX), a new dual specificity phosphatase related to VH1 related (VHR).". J. Biol. Chem. 277 (7): 5524–8. doi:10.1074/jbc.M107653200. PMID 11733513.
• Chen AJ, Zhou G, Juan T; et al. (2002). "The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway.". J. Biol. Chem. 277 (39): 36592–601. doi:10.1074/jbc.M200453200. PMID 12138158.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Alonso A, Narisawa S, Bogetz J; et al. (2004). "VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX.". J. Biol. Chem. 279 (31): 32586–91. doi:10.1074/jbc.M403442200. PMID 15138252.
• Fortna A, Kim Y, MacLaren E; et al. (2004). "Lineage-specific gene duplication and loss in human and great ape evolution.". PLoS Biol. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMC 449870. PMID 15252450.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yokota T, Nara Y, Kashima A; et al. (2007). "Crystal structure of human dual specificity phosphatase, JNK stimulatory phosphatase-1, at 1.5 A resolution.". Proteins 66 (2): 272–8. doi:10.1002/prot.21152. PMID 17068812.
• Sekine Y, Ikeda O, Hayakawa Y; et al. (2007). "DUSP22/LMW-DSP2 regulates estrogen receptor-alpha-mediated signaling through dephosphorylation of Ser-118.". Oncogene 26 (41): 6038–49. doi:10.1038/sj.onc.1210426. PMID 17384676.