TENC1

Tensin 2
PDB rendering based on 2dkq.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2DKQ​, 2KNO​, 2L6K​, 2LOZ​, 3HQC​
Identifiers
Symbols	TNS2 ; C1-TEN; C1TEN; TENC1
External IDs	OMIM: 607717 MGI: 2387586 HomoloGene: 37077 GeneCards: TNS2 Gene
Gene ontology Molecular function • phosphoprotein phosphatase activity • protein binding • kinase binding • metal ion binding Cellular component • intracellular • plasma membrane • focal adhesion Biological process • kidney development • protein dephosphorylation • negative regulation of cell proliferation • response to muscle activity • cellular homeostasis • collagen metabolic process • multicellular organism growth • intracellular signal transduction • multicellular organismal homeostasis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23371	209039
Ensembl	ENSG00000111077	ENSMUSG00000037003
UniProt	Q63HR2	Q8CGB6
RefSeq (mRNA)	NM_015319	NM_153533
RefSeq (protein)	NP_056134	NP_705761
Location (UCSC)	Chr 12: 53.05 – 53.06 Mb	Chr 15: 102.1 – 102.12 Mb
PubMed search

Tensin-like C1 domain-containing phosphatase is an enzyme that in humans is encoded by the TENC1 gene.^[1]

The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.^[1]

Interactions

TENC1 has been shown to interact with AXL receptor tyrosine kinase.^[2]

References

1. "Entrez Gene: TENC1 tensin like C1 domain containing phosphatase (tensin 2)".
2. Hafizi, Sassan; Alindri Filiz; Karlsson Roger; Dahlbäck Björn (Dec 2002). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin". Biochem. Biophys. Res. Commun. (United States) 299 (5): 793–800. doi:10.1016/S0006-291X(02)02718-3. ISSN 0006-291X. PMID 12470648.

Further reading

• Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
• Chen H, Duncan IC, Bozorgchami H, Lo SH (2002). "Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration.". Proc. Natl. Acad. Sci. U.S.A. 99 (2): 733–8. doi:10.1073/pnas.022518699. PMC 117374. PMID 11792844.
• Hafizi S, Alindri F, Karlsson R, Dahlbäck B (2003). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin.". Biochem. Biophys. Res. Commun. 299 (5): 793–800. doi:10.1016/S0006-291X(02)02718-3. PMID 12470648.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Calderwood DA, Fujioka Y, de Pereda JM, et al. (2003). "Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2272–7. doi:10.1073/pnas.262791999. PMC 151330. PMID 12606711.
• Hu Y, Fang X, Dunham SM, et al. (2004). "90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling.". J. Biol. Chem. 279 (28): 29325–35. doi:10.1074/jbc.M311144200. PMID 15117958.
• Hafizi S, Ibraimi F, Dahlbäck B (2006). "C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration.". FASEB J. 19 (8): 971–3. doi:10.1096/fj.04-2532fje. PMID 15817639.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Yam JW, Ko FC, Chan CY, et al. (2006). "Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma.". Hepatology 44 (4): 881–90. doi:10.1002/hep.21339. PMID 17006924.