PTPN14

Protein tyrosine phosphatase, non-receptor type 14

PDB rendering based on 2bzl.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PTPN14 ; PEZ; PTP36
External IDs OMIM: 603155 MGI: 102467 HomoloGene: 3941 GeneCards: PTPN14 Gene
EC number 3.1.3.48
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 5784 19250
Ensembl ENSG00000152104 ENSMUSG00000026604
UniProt Q15678 Q62130
RefSeq (mRNA) NM_005401 NM_001033287
RefSeq (protein) NP_005392 NP_033002
Location (UCSC) Chr 1:
214.35 – 214.55 Mb		 Chr 1:
189.73 – 189.88 Mb
PubMed search

Tyrosine-protein phosphatase non-receptor type 14 is an enzyme that in humans is encoded by the PTPN14 gene.[1][2]

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. The specific function of this PTP has not yet been determined.[2]

Interactions

PTPN14 has been shown to interact with Beta-catenin.[3]

References

  1. ↑ Smith AL, Mitchell PJ, Shipley J, Gusterson BA, Rogers MV, Crompton MR (Apr 1995). "Pez: a novel human cDNA encoding protein tyrosine phosphatase- and ezrin-like domains". Biochemical and Biophysical Research Communications 209 (3): 959–65. doi:10.1006/bbrc.1995.1591. PMID 7733990.
  2. 1 2 "Entrez Gene: PTPN14 protein tyrosine phosphatase, non-receptor type 14".
  3. ↑ Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y (Jun 2003). "The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin". Molecular Biology of the Cell 14 (6): 2520–9. doi:10.1091/mbc.E02-09-0577. PMC 194899. PMID 12808048.

Further reading

  • Gyapay G, Morissette J, Vignal A, Dib C, Fizames C, Millasseau P, Marc S, Bernardi G, Lathrop M, Weissenbach J (Jun 1994). "The 1993-94 Généthon human genetic linkage map". Nature Genetics 7 (2 Spec No): 246–339. doi:10.1038/ng0694supp-246. PMID 7545953. 
  • Ogata M, Takada T, Mori Y, Oh-hora M, Uchida Y, Kosugi A, Miyake K, Hamaoka T (Apr 1999). "Effects of overexpression of PTP36, a putative protein tyrosine phosphatase, on cell adhesion, cell growth, and cytoskeletons in HeLa cells". The Journal of Biological Chemistry 274 (18): 12905–9. doi:10.1074/jbc.274.18.12905. PMID 10212280. 
  • Ogata M, Takada T, Mori Y, Uchida Y, Miki T, Okuyama A, Kosugi A, Sawada M, Oh-hora M, Hamaoka T (Jul 1999). "Regulation of phosphorylation level and distribution of PTP36, a putative protein tyrosine phosphatase, by cell-substrate adhesion". The Journal of Biological Chemistry 274 (29): 20717–24. doi:10.1074/jbc.274.29.20717. PMID 10400706. 
  • Aoyama K, Matsuda T, Aoki N (Dec 1999). "Characterization of newly identified four isoforms for a putative cytosolic protein tyrosine phosphatase PTP36". Biochemical and Biophysical Research Communications 266 (2): 523–31. doi:10.1006/bbrc.1999.1845. PMID 10600535. 
  • Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y (Sep 2000). "Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to the nucleus is associated with induction of cell proliferation". Journal of Cell Science. 113 ( Pt 17) (17): 3117–23. PMID 10934049. 
  • Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y (Jun 2003). "The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin". Molecular Biology of the Cell 14 (6): 2520–9. doi:10.1091/mbc.E02-09-0577. PMC 194899. PMID 12808048. 
  • Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. 
  • Barr AJ, Debreczeni JE, Eswaran J, Knapp S (Jun 2006). "Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution". Proteins 63 (4): 1132–6. doi:10.1002/prot.20958. PMID 16534812. 
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
This article is issued from Wikipedia - version of the Saturday, November 21, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.