GUCY1A2

Guanylate cyclase 1, soluble, alpha 2
Identifiers
Symbols	GUCY1A2 ; GC-SA2; GUC1A2
External IDs	OMIM: 601244 MGI: 2660877 HomoloGene: 47953 ChEMBL: 3303 GeneCards: GUCY1A2 Gene
EC number	4.6.1.2
Gene ontology Molecular function • guanylate cyclase activity • GTP binding • heme binding Cellular component • cytoplasm Biological process • cGMP biosynthetic process • signal transduction • blood coagulation • positive regulation of cGMP biosynthetic process • intracellular signal transduction Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2977	234889
Ensembl	ENSG00000152402	ENSMUSG00000041624
UniProt	P33402	F8VQK3
RefSeq (mRNA)	NM_000855	NM_001033322
RefSeq (protein)	NP_000846	NP_001028494
Location (UCSC)	Chr 11: 106.67 – 107.02 Mb	Chr 9: 3.53 – 3.9 Mb
PubMed search

Guanylate cyclase soluble subunit alpha-2 is an enzyme that in humans is encoded by the GUCY1A2 gene.^[1][2]

References

1. Harteneck C, Wedel B, Koesling D, Malkewitz J, Bohme E, Schultz G (Jan 1992). "Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme". FEBS Lett 292 (1–2): 217–22. doi:10.1016/0014-5793(91)80871-Y. PMID 1683630.
2. "Entrez Gene: GUCY1A2 guanylate cyclase 1, soluble, alpha 2".

Further reading

• Baba H, Suzuki T, Arai H, Emson PC (2004). "Expression of nNOS and soluble guanylate cyclase in schizophrenic brain". NeuroReport 15 (4): 677–80. doi:10.1097/00001756-200403220-00020. PMID 15094474.
• Bellamy TC, Wood J, Garthwaite J (2002). "On the activation of soluble guanylyl cyclase by nitric oxide". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 507–10. doi:10.1073/pnas.012368499. PMC 117590. PMID 11752394.
• Russwurm M, Wittau N, Koesling D (2002). "Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes". J. Biol. Chem. 276 (48): 44647–52. doi:10.1074/jbc.M105587200. PMID 11572861.
• Bamberger AM, Koglin M, Kempfert J, et al. (2001). "Expression and tissue localization of soluble guanylyl cyclase in the human placenta using novel antibodies directed against the alpha(2) subunit". J. Clin. Endocrinol. Metab. 86 (2): 909–12. doi:10.1210/jc.86.2.909. PMID 11158065.
• Budworth J, Meillerais S, Charles I, Powell K (1999). "Tissue distribution of the human soluble guanylate cyclases". Biochem. Biophys. Res. Commun. 263 (3): 696–701. doi:10.1006/bbrc.1999.1444. PMID 10512742.
• Yu F, Warburton D, Wellington S, Danziger RS (1997). "Assignment of GUCIA2, the gene coding for the alpha 2 subunit of soluble guanylyl cyclase, to position 11q21-q22 on human chromosome 11". Genomics 33 (2): 334–6. doi:10.1006/geno.1996.0208. PMID 8660992.
• Behrends S, Harteneck C, Schultz G, Koesling D (1995). "A variant of the alpha 2 subunit of soluble guanylyl cyclase contains an insert homologous to a region within adenylyl cyclases and functions as a dominant negative protein". J. Biol. Chem. 270 (36): 21109–13. doi:10.1074/jbc.270.36.21109. PMID 7673142.