NPR1

Natriuretic peptide receptor 1
Identifiers
Symbols	NPR1 ; ANPRA; ANPa; GUC2A; GUCY2A; NPRA
External IDs	OMIM: 108960 MGI: 97371 HomoloGene: 37367 ChEMBL: 1988 GeneCards: NPR1 Gene
EC number	4.6.1.2
Gene ontology Molecular function • guanylate cyclase activity • protein kinase activity • ATP binding • GTP binding • G-protein coupled peptide receptor activity • natriuretic peptide receptor activity • peptide hormone binding • protein kinase binding • hormone binding Cellular component • intracellular • integral component of plasma membrane • receptor complex Biological process • cGMP biosynthetic process • protein phosphorylation • cell surface receptor signaling pathway • receptor guanylyl cyclase signaling pathway • G-protein coupled receptor signaling pathway • body fluid secretion • regulation of blood pressure • negative regulation of angiogenesis • negative regulation of cell growth • positive regulation of cGMP biosynthetic process • intracellular signal transduction • positive regulation of urine volume • positive regulation of renal sodium excretion • regulation of vasodilation • dopamine metabolic process • regulation of vascular permeability • negative regulation of smooth muscle cell proliferation • regulation of blood vessel size Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4881	18160
Ensembl	ENSG00000169418	ENSMUSG00000027931
UniProt	P16066	P18293
RefSeq (mRNA)	NM_000906	NM_008727
RefSeq (protein)	NP_000897	NP_032753
Location (UCSC)	Chr 1: 153.68 – 153.69 Mb	Chr 3: 90.45 – 90.47 Mb
PubMed search

Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR1 gene.

Function

NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP and BNP, respectively).^[1]

It is localized in the kidney^[2] where it results in natriuresis upon binding to natriuretic peptides. However, it is found in even greater quantity in the lungs and adipocytes.^[2]

References

1. "Entrez Gene: NPR1 natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)".
2. BioGPS > NPR1 Retrieved Nov 2010 Archived November 27, 2010 at the Wayback Machine

Further reading

• Pandey KN (2002). "Intracellular trafficking and metabolic turnover of ligand-bound guanylyl cyclase/atrial natriuretic peptide receptor-A into subcellular compartments.". Mol. Cell. Biochem. 230 (1–2): 61–72. doi:10.1023/A:1014240006767. PMID 11952097.
• Lucarelli K, Iacoviello M, Dessì-Fulgheri P, et al. (2003). "[Natriuretic peptides and essential arterial hypertension]". Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology 3 (11): 1085–91. PMID 12506509.
• Pandey KN (2005). "Internalization and trafficking of guanylyl cyclase/natriuretic peptide receptor-A". Peptides 26 (6): 985–1000. doi:10.1016/j.peptides.2004.12.020. PMID 15911067.
• Garg R, Pandey KN (2005). "Regulation of guanylyl cyclase/natriuretic peptide receptor-A gene expression". Peptides 26 (6): 1009–23. doi:10.1016/j.peptides.2004.09.022. PMID 15911069.

See also

• Atrial natriuretic peptide receptor

External links

• NPR1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.