Bromochlorosalicylanilide

Bromochlorosalicylanilide
Systematic (IUPAC) name

5-Bromo-N-(4-chlorophenyl)-2-hydroxybenzamide
Identifiers
CAS Number	3679-64-9
ATC code	D01AE01 (WHO)
PubChem	CID 77254
ChemSpider	69679
UNII	6GK715PWMQ^Y
Synonyms	Bromosalicylchloranilide Multifungin Salifungin
Chemical data
SMILES Brc2cc(C(=O)Nc1ccc(Cl)cc1)c(O)cc2

Bromochlorosalicylanilide is an antifungal.^[1] It may cause allergic contact dermatitis in some individuals.^[2]

References

↑ Weuffen, Wolfgang; Wagner, Guenther; Singer, Dietmar; Petermann, M. (1966). "2-Hydroxythiobenzamides and 2-hydroxythiobenzanilides. III. Fungicidal properties". Pharmazie 21 (10): 613–19.
↑ Buckley D B (1986). "Allergic contact dermatitis to bromsalicylchloranilide". Contact dermatitis 14 (5): 319. doi:10.1111/j.1600-0536.1986.tb05290.x. PMID 3743047.

Antifungals (D01 and J02)

Wall/
membrane

Ergosterol
inhibitors

Azoles
(lanosterol 14
alpha-demethylase inhibitors)

Imidazoles	Topical: bifonazole^‡ chlormidazole^‡ croconazole^‡ fenticonazole^‡ isoconazole^‡ luliconazole neticonazole^‡ omoconazole^‡ butoconazole clotrimazole^# econazole ketoconazole miconazole^# oxiconazole sertaconazole sulconazole tioconazole Systemic: ketoconazole

Triazoles	Topical: fluconazole^#, fosfluconazole efinaconazole terconazole Systemic: hexaconazole^‡ isavuconazole fluconazole^# itraconazole posaconazole voriconazole Unknown: albaconazole^‡

Thiazoles	Topical: abafungin^‡

Polyene antimycotics
(ergosterol binding)

Topical: hamycin^‡
natamycin
nystatin^#
Systemic: amphotericin B^#, hamycin^‡

Allylamines
(squalene monooxygenase
inhibitors)

Topical: amorolfine^‡
butenafine
naftifine
terbinafine
Systemic: terbinafine

β-glucan synthase
inhibitors

Intracellular

Pyrimidine analogues/ thymidylate synthase inhibitors	flucytosine^#

Mitotic inhibitors	griseofulvin^#

Aminoacyl tRNA synthetase inhibitors	tavaborole

Others

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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