Tolciclate

Tolciclate
Clinical data


AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	50838-36-3^Y
ATC code	D01AE19 (WHO)
PubChem	CID 5506
ChemSpider	5305^N
UNII	T3TZ02X2AZ^Y
KEGG	D01384^Y
Chemical data
Formula	C₂₀H₂₁NOS
Molar mass	323.45 g/mol
SMILES Cc1cccc(c1)N(C)C(=S)Oc2ccc3c(c2)C4CCC3C4
InChI InChI=1S/C20H21NOS/c1-13-4-3-5-16(10-13)21(2)20(23)22-17-8-9-18-14-6-7-15(11-14)19(18)12-17/h3-5,8-10,12,14-15H,6-7,11H2,1-2H3^N Key:CANCCLAKQQHLNK-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Tolciclate is an antifungal.^[1]^[2]

References

↑ Ryder, N. S.; Frank, I.; Dupont, M. C. (May 1986). "Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate". Antimicrobial Agents and Chemotherapy 29 (5): 858–860. doi:10.1128/aac.29.5.858. PMC 284167. PMID 3524433.
↑ Bianchi, A.; Monti, G.; de Carneri, I. (September 1977). "Tolciclate: further antimycotic studies". Antimicrobial Agents and Chemotherapy 12 (3): 429–430. doi:10.1128/aac.12.3.429. PMC 429931. PMID 907333.

Antifungals (D01 and J02)

Wall/
membrane

Ergosterol
inhibitors

Azoles
(lanosterol 14
alpha-demethylase inhibitors)

Imidazoles	Topical: bifonazole^‡ chlormidazole^‡ croconazole^‡ fenticonazole^‡ isoconazole^‡ luliconazole neticonazole^‡ omoconazole^‡ butoconazole clotrimazole^# econazole ketoconazole miconazole^# oxiconazole sertaconazole sulconazole tioconazole Systemic: ketoconazole

Triazoles	Topical: fluconazole^#, fosfluconazole efinaconazole terconazole Systemic: hexaconazole^‡ isavuconazole fluconazole^# itraconazole posaconazole voriconazole Unknown: albaconazole^‡

Thiazoles	Topical: abafungin^‡

Polyene antimycotics
(ergosterol binding)

Topical: hamycin^‡
natamycin
nystatin^#
Systemic: amphotericin B^#, hamycin^‡

Allylamines
(squalene monooxygenase
inhibitors)

Topical: amorolfine^‡
butenafine
naftifine
terbinafine
Systemic: terbinafine

β-glucan synthase
inhibitors

Intracellular

Pyrimidine analogues/ thymidylate synthase inhibitors	flucytosine^#

Mitotic inhibitors	griseofulvin^#

Aminoacyl tRNA synthetase inhibitors	tavaborole

Others

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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Tolciclate

See also

References