Croconazole

Croconazole
Systematic (IUPAC) name

1-(1-{2-[(3-chlorophenyl)methoxy]phenyl}ethenyl)-1H-imidazole
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Topical
Legal status
Legal status	℞ (Prescription only)
Identifiers
CAS Number	77175-51-0
ATC code	none
PubChem	CID 2880
ChemSpider	2777
UNII	446254H55G^Y
KEGG	D07752
ChEMBL	CHEMBL27289
Chemical data
Formula	C₁₈H₁₅ClN₂O
Molar mass	310.77 g/mol
SMILES Clc1cccc(c1)COc3c(\C(=C)n2ccnc2)cccc3

Croconazole (INN) is an imidazole antifungal.

External links

Croconazole

Antifungals (D01 and J02)

Wall/
membrane

Ergosterol
inhibitors

Azoles
(lanosterol 14
alpha-demethylase inhibitors)

Imidazoles	Topical: bifonazole^‡ chlormidazole^‡ croconazole^‡ fenticonazole^‡ isoconazole^‡ luliconazole neticonazole^‡ omoconazole^‡ butoconazole clotrimazole^# econazole ketoconazole miconazole^# oxiconazole sertaconazole sulconazole tioconazole Systemic: ketoconazole

Triazoles	Topical: fluconazole^#, fosfluconazole efinaconazole terconazole Systemic: hexaconazole^‡ isavuconazole fluconazole^# itraconazole posaconazole voriconazole Unknown: albaconazole^‡

Thiazoles	Topical: abafungin^‡

Polyene antimycotics
(ergosterol binding)

Topical: hamycin^‡
natamycin
nystatin^#
Systemic: amphotericin B^#, hamycin^‡

Allylamines
(squalene monooxygenase
inhibitors)

Topical: amorolfine^‡
butenafine
naftifine
terbinafine
Systemic: terbinafine

β-glucan synthase
inhibitors

Intracellular

Pyrimidine analogues/ thymidylate synthase inhibitors	flucytosine^#

Mitotic inhibitors	griseofulvin^#

Aminoacyl tRNA synthetase inhibitors	tavaborole

Others

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

This article is issued from Wikipedia - version of the Tuesday, April 05, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.