Dimazole

Dimazole
Systematic (IUPAC) name

[6-(2-Diethylamino-ethoxy)-benzothiazol-2-yl]-dimethyl-amine
Identifiers
CAS Number	95-27-2
ATC code	D01AE17 (WHO)
PubChem	CID 8708
ChemSpider	8384
UNII	2KL01R8ZV1^Y
Chemical data
Formula	C₁₅H₂₃N₃OS
Molar mass	293.42762
SMILES CCN(CC)CCOc1ccc2c(c1)sc(n2)N(C)C
InChI InChI=1S/C15H23N3OS/c1-5-18(6-2)9-10-19-12-7-8-13-14(11-12)20-15(16-13)17(3)4/h7-8,11H,5-6,9-10H2,1-4H3 Key:WGMYEOIMVYADRJ-UHFFFAOYSA-N
Physical data
Melting point	195 to 204 °C (383 to 399 °F)
(verify)

Dimazole (or diamthazole) is an antifungal.^[1]

Synthesis

Diamthazole synthesis: U.S. Patent 2,578,757

References

↑ Drugs.com: diamthazole dihydrochloride

Antifungals (D01 and J02)

Wall/
membrane

Ergosterol
inhibitors

Azoles
(lanosterol 14
alpha-demethylase inhibitors)

Imidazoles	Topical: bifonazole^‡ chlormidazole^‡ croconazole^‡ fenticonazole^‡ isoconazole^‡ luliconazole neticonazole^‡ omoconazole^‡ butoconazole clotrimazole^# econazole ketoconazole miconazole^# oxiconazole sertaconazole sulconazole tioconazole Systemic: ketoconazole

Triazoles	Topical: fluconazole^#, fosfluconazole efinaconazole terconazole Systemic: hexaconazole^‡ isavuconazole fluconazole^# itraconazole posaconazole voriconazole Unknown: albaconazole^‡

Thiazoles	Topical: abafungin^‡

Polyene antimycotics
(ergosterol binding)

Topical: hamycin^‡
natamycin
nystatin^#
Systemic: amphotericin B^#, hamycin^‡

Allylamines
(squalene monooxygenase
inhibitors)

Topical: amorolfine^‡
butenafine
naftifine
terbinafine
Systemic: terbinafine

β-glucan synthase
inhibitors

Intracellular

Pyrimidine analogues/ thymidylate synthase inhibitors	flucytosine^#

Mitotic inhibitors	griseofulvin^#

Aminoacyl tRNA synthetase inhibitors	tavaborole

Others

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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