Chlorophetanol

Chlorophetanol
Systematic (IUPAC) name

2-(4-chlorophenoxy)ethanol
Identifiers
CAS Number	1892-43-9^Y
ATC code	D01AE06 (WHO)
PubChem	CID 15907
ChemSpider	15118^N
UNII	Q73I5T98DA^N
Chemical data
Formula	C₈H₉ClO₂
Molar mass	172.61 g/mol
SMILES Clc1ccc(OCCO)cc1
InChI InChI=1S/C8H9ClO2/c9-7-1-3-8(4-2-7)11-6-5-10/h1-4,10H,5-6H2^N Key:GEGSSUSEWOHAFE-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Chlorophetanol is an antifungal.^[1]

References

↑ Zsolnai, Tibor (1960). "Action of new fungicides. I. Phenol derivatives". Biochemical Pharmacology 5: 1–19. doi:10.1016/0006-2952(60)90002-2.

Antifungals (D01 and J02)

Wall/
membrane

Ergosterol
inhibitors

Azoles
(lanosterol 14
alpha-demethylase inhibitors)

Imidazoles	Topical: bifonazole^‡ chlormidazole^‡ croconazole^‡ fenticonazole^‡ isoconazole^‡ luliconazole neticonazole^‡ omoconazole^‡ butoconazole clotrimazole^# econazole ketoconazole miconazole^# oxiconazole sertaconazole sulconazole tioconazole Systemic: ketoconazole

Triazoles	Topical: fluconazole^#, fosfluconazole efinaconazole terconazole Systemic: hexaconazole^‡ isavuconazole fluconazole^# itraconazole posaconazole voriconazole Unknown: albaconazole^‡

Thiazoles	Topical: abafungin^‡

Polyene antimycotics
(ergosterol binding)

Topical: hamycin^‡
natamycin
nystatin^#
Systemic: amphotericin B^#, hamycin^‡

Allylamines
(squalene monooxygenase
inhibitors)

Topical: amorolfine^‡
butenafine
naftifine
terbinafine
Systemic: terbinafine

β-glucan synthase
inhibitors

Intracellular

Pyrimidine analogues/ thymidylate synthase inhibitors	flucytosine^#

Mitotic inhibitors	griseofulvin^#

Aminoacyl tRNA synthetase inhibitors	tavaborole

Others

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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