Ticlatone

Ticlatone
Systematic (IUPAC) name


6-chloro-1,2-benzothiazol-3(2H)-one
Clinical data
Trade names	Landromil
Identifiers
CAS Number	70-10-0^Y
ATC code	D01AE08 (WHO)
PubChem	CID 6258
ChemSpider	6022^N
UNII	BHW384Q9GI^Y
KEGG	D06139^Y
Chemical data
Formula	C₇H₄ClNOS
Molar mass	185.63 g/mol
SMILES c1cc2c(cc1Cl)s[nH]c2=O
InChI InChI=1S/C7H4ClNOS/c8-4-1-2-5-6(3-4)11-9-7(5)10/h1-3H,(H,9,10)^N Key:POPOYOKQQAEISW-UHFFFAOYSA-N^N
Physical data
Melting point	270 to 273 °C (518 to 523 °F)
^NY (what is this?) (verify)

Ticlatone (trade name Landromil) is an antifungal.^[1]

References

↑ Landromil (Ticlatone)

Antifungals (D01 and J02)

Wall/
membrane

Ergosterol
inhibitors

Azoles
(lanosterol 14
alpha-demethylase inhibitors)

Imidazoles	Topical: bifonazole^‡ chlormidazole^‡ croconazole^‡ fenticonazole^‡ isoconazole^‡ luliconazole neticonazole^‡ omoconazole^‡ butoconazole clotrimazole^# econazole ketoconazole miconazole^# oxiconazole sertaconazole sulconazole tioconazole Systemic: ketoconazole

Triazoles	Topical: fluconazole^#, fosfluconazole efinaconazole terconazole Systemic: hexaconazole^‡ isavuconazole fluconazole^# itraconazole posaconazole voriconazole Unknown: albaconazole^‡

Thiazoles	Topical: abafungin^‡

Polyene antimycotics
(ergosterol binding)

Topical: hamycin^‡
natamycin
nystatin^#
Systemic: amphotericin B^#, hamycin^‡

Allylamines
(squalene monooxygenase
inhibitors)

Topical: amorolfine^‡
butenafine
naftifine
terbinafine
Systemic: terbinafine

β-glucan synthase
inhibitors

Intracellular

Pyrimidine analogues/ thymidylate synthase inhibitors	flucytosine^#

Mitotic inhibitors	griseofulvin^#

Aminoacyl tRNA synthetase inhibitors	tavaborole

Others

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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