RCOR1

REST corepressor 1
PDB rendering based on 2iw5.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2IW5​, 2UXN​, 2UXX​, 2V1D​, 2X0L​, 2XAF​, 2XAG​, 2XAH​, 2XAJ​, 2XAQ​, 2XAS​, 2Y48​, 3ZMS​, 3ZMT​, 3ZMU​, 3ZMV​, 3ZMZ​, 3ZN0​, 3ZN1​, 4BAY​, 4KUM​, 4UV8​, 4UV9​, 4UVA​, 4UVB​, 4UVC​, 4UXN​
Identifiers
Symbols	RCOR1 ; COREST; RCOR
External IDs	OMIM: 607675 MGI: 106340 HomoloGene: 32246 GeneCards: RCOR1 Gene
Gene ontology Molecular function • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • transcription regulatory region DNA binding Cellular component • nucleus • nucleoplasm • transcriptional repressor complex Biological process • negative regulation of transcription from RNA polymerase II promoter • chromatin organization • transcription, DNA-templated • blood coagulation • viral process • negative regulation of transcription, DNA-templated • histone H4 deacetylation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23186	217864
Ensembl	ENSG00000089902	ENSMUSG00000037896
UniProt	Q9UKL0	Q8CFE3
RefSeq (mRNA)	NM_015156	NM_198023
RefSeq (protein)	NP_055971	NP_932140
Location (UCSC)	Chr 14: 102.59 – 102.73 Mb	Chr 12: 111.04 – 111.12 Mb
PubMed search

REST corepressor 1 also known as CoREST is a protein that in humans is encoded by the RCOR1 gene.^[1][2]

Function

This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor).^[2]

Interactions

RCOR1 has been shown to interact with

• HDAC1,^[3][4]
• HDAC2,^[3][4]
• HMG20B,^[3]
• REST^[1] and
• PHF21A.^[3][5]

References

1. Andrés ME, Burger C, Peral-Rubio MJ, Battaglioli E, Anderson ME, Grimes J, Dallman J, Ballas N, Mandel G (September 1999). "CoREST: a functional corepressor required for regulation of neural-specific gene expression". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9873–8. doi:10.1073/pnas.96.17.9873. PMC 22303. PMID 10449787.
2. "Entrez Gene: RCOR1 REST corepressor 1".
3. Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7420–5. doi:10.1073/pnas.112008599. PMC 124246. PMID 12032298.
4. You A, Tong JK, Grozinger CM, Schreiber SL (February 2001). "CoREST is an integral component of the CoREST- human histone deacetylase complex". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1454–8. doi:10.1073/pnas.98.4.1454. PMC 29278. PMID 11171972.
5. Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (September 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun. 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272.

Further reading

• Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Grimes JA, Nielsen SJ, Battaglioli E, Miska EA, Speh JC, Berry DL, Atouf F, Holdener BC, Mandel G, Kouzarides T (2000). "The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex". J. Biol. Chem. 275 (13): 9461–7. doi:10.1074/jbc.275.13.9461. PMID 10734093.
• Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Humphrey GW, Wang Y, Russanova VR, Hirai T, Qin J, Nakatani Y, Howard BH (2001). "Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1". J. Biol. Chem. 276 (9): 6817–24. doi:10.1074/jbc.M007372200. PMID 11102443.
• You A, Tong JK, Grozinger CM, Schreiber SL (2001). "CoREST is an integral component of the CoREST- human histone deacetylase complex". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1454–8. doi:10.1073/pnas.98.4.1454. PMC 29278. PMID 11171972.
• Ballas N, Battaglioli E, Atouf F, Andres ME, Chenoweth J, Anderson ME, Burger C, Moniwa M, Davie JR, Bowers WJ, Federoff HJ, Rose DW, Rosenfeld MG, Brehm P, Mandel G (2001). "Regulation of neuronal traits by a novel transcriptional complex". Neuron 31 (3): 353–65. doi:10.1016/S0896-6273(01)00371-3. PMID 11516394.
• Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7420–5. doi:10.1073/pnas.112008599. PMC 124246. PMID 12032298.
• Battaglioli E, Andrés ME, Rose DW, Chenoweth JG, Rosenfeld MG, Anderson ME, Mandel G (2002). "REST repression of neuronal genes requires components of the hSWI.SNF complex". J. Biol. Chem. 277 (43): 41038–45. doi:10.1074/jbc.M205691200. PMID 12192000.
• Lunyak VV, Burgess R, Prefontaine GG, Nelson C, Sze SH, Chenoweth J, Schwartz P, Pevzner PA, Glass C, Mandel G, Rosenfeld MG (2002). "Corepressor-dependent silencing of chromosomal regions encoding neuronal genes". Science 298 (5599): 1747–52. doi:10.1126/science.1076469. PMID 12399542.
• Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". J. Biol. Chem. 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763.
• Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun. 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272.
• Gu H, Liang Y, Mandel G, Roizman B (2005). "Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells". Proc. Natl. Acad. Sci. U.S.A. 102 (21): 7571–6. doi:10.1073/pnas.0502658102. PMC 1140450. PMID 15897453.
• Lee MG, Wynder C, Cooch N, Shiekhattar R (2005). "An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation". Nature 437 (7057): 432–5. doi:10.1038/nature04021. PMID 16079794.
• Shi YJ, Matson C, Lan F, Iwase S, Baba T, Shi Y (2005). "Regulation of LSD1 histone demethylase activity by its associated factors". Mol. Cell 19 (6): 857–64. doi:10.1016/j.molcel.2005.08.027. PMID 16140033.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.