RhoGEF domain
| RhoGEF domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein.[1] | |||||||||
| Identifiers | |||||||||
| Symbol | RhoGEF | ||||||||
| Pfam | PF00621 | ||||||||
| InterPro | IPR000219 | ||||||||
| SMART | RhoGEF | ||||||||
| SCOP | 1dbh | ||||||||
| SUPERFAMILY | 1dbh | ||||||||
| OPM protein | 1xd4 | ||||||||
| |||||||||
RhoGEF domain is a structural domain of guanine nucleotide exchange factors for Rho/Rac/Cdc42-like GTPases. It is also called "Dbl-homologous" (DH) domain.
Subfamilies
- Guanine-nucleotide dissociation stimulator, CDC24 IPR001331
Human proteins containing this domain
ABR; AKAP13; ARHGEF1; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF15; ARHGEF16; ARHGEF17; ARHGEF18; ARHGEF19; ARHGEF2; ARHGEF3; ARHGEF4; ARHGEF5; ARHGEF6; ARHGEF7; ARHGEF9; ASEF2; BCR; C9orf100; DEPDC2; DNMBP; ECT2; FARP1; FARP2; FGD1; FGD2; FGD3; FGD4; FGD5; FGD6; GEFT; ITSN1; ITSN2; KALRN; LFDH; MCF2; MCF2L; MCF2L2; NET1; NGEF; OBSCN; PLEKHG1; PLEKHG2; PLEKHG3; PLEKHG4; PLEKHG5; PLEKHG6; PREX1; RASGRF1; SGEF; SOS1; SOS2; SPATA13; TIAM1; TIAM2; TRIO; VAV1; VAV2; VAV3;
Notes
- ↑ Soisson, S.; Nimnual, A.; Uy, M.; Bar-Sagi, D.; Kuriyan, J. (1998). "Crystal Structure of the Dbl and Pleckstrin Homology Domains from the Human Son of Sevenless Protein". Cell 95 (2): 259–268. doi:10.1016/S0092-8674(00)81756-0. PMID 9790532.
References
- Cerione, R. A.; Zheng, Y. (1996). "The Dbl family of oncogenes". Current opinion in cell biology 8 (2): 216–222. doi:10.1016/s0955-0674(96)80068-8. PMID 8791419.
- Hart, M. J.; Eva, A.; Evans, T.; Aaronson, S. A.; Cerione, R. A. (1991). "Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product". Nature 354 (6351): 311–314. doi:10.1038/354311a0. PMID 1956381.
- Tan, E. C.; Leung, T.; Manser, E.; Lim, L. (1993). "The human active breakpoint cluster region-related gene encodes a brain protein with homology to guanine nucleotide exchange proteins and GTPase-activating proteins". The Journal of Biological Chemistry 268 (36): 27291–27298. PMID 8262969.
- Soisson, S.; Nimnual, A.; Uy, M.; Bar-Sagi, D.; Kuriyan, J. (1998). "Crystal Structure of the Dbl and Pleckstrin Homology Domains from the Human Son of Sevenless Protein". Cell 95 (2): 259–268. doi:10.1016/S0092-8674(00)81756-0. PMID 9790532.