Desmoglein-3

Desmoglein 3
Identifiers
Symbols	DSG3 ; CDHF6; PVA
External IDs	OMIM: 169615 MGI: 99499 HomoloGene: 55513 GeneCards: DSG3 Gene
Gene ontology Molecular function • calcium ion binding Cellular component • cytosol • plasma membrane • integral component of membrane • desmosome • extracellular exosome Biological process • apoptotic process • cellular component disassembly involved in execution phase of apoptosis • homophilic cell adhesion via plasma membrane adhesion molecules • programmed cell death Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1830	13512
Ensembl	ENSG00000134757	ENSMUSG00000056632
UniProt	P32926	n/a
RefSeq (mRNA)	NM_001944	NM_030596
RefSeq (protein)	NP_001935	NP_085099
Location (UCSC)	Chr 18: 31.45 – 31.48 Mb	Chr 18: 20.51 – 20.54 Mb
PubMed search

Desmoglein-3 is a protein that in humans is encoded by the DSG3 gene.^[1][2]

Function

Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.^[2]

Interactions

Desmoglein 3 has been shown to interact with PKP3.^[3]

See also

• Desmoglein
• List of target antigens in pemphigus
• List of conditions caused by problems with junctional proteins

References

1. Arnemann J, Spurr NK, Buxton RS (Jul 1992). "The human gene (DSG3) coding for the pemphigus vulgaris antigen is, like the genes coding for the other two known desmogleins, assigned to chromosome 18". Hum Genet 89 (3): 347–50. doi:10.1007/bf00220557. PMID 1601426.
2. "Entrez Gene: DSG3 desmoglein 3 (pemphigus vulgaris antigen)".
3. Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F (April 2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. 161 (2): 403–16. doi:10.1083/jcb.200303036. PMC 2172904. PMID 12707304.

Further reading

• Amagai M, Klaus-Kovtun V, Stanley JR (1992). "Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion". Cell 67 (5): 869–77. doi:10.1016/0092-8674(91)90360-B. PMID 1720352.
• Roh JY, Stanley JR (1995). "Plakoglobin binding by human Dsg3 (pemphigus vulgaris antigen) in keratinocytes requires the cadherin-like intracytoplasmic segment". J. Invest. Dermatol. 104 (5): 720–4. doi:10.1111/1523-1747.ep12606963. PMID 7738346.
• Wang Y, Amagai M, Minoshima S; et al. (1994). "The human genes for desmogleins (DSG1 and DSG3) are located in a small region on chromosome 18q12". Genomics 20 (3): 492–5. doi:10.1006/geno.1994.1207. PMID 8034325.
• Schäfer S, Koch PJ, Franke WW (1994). "Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins". Exp. Cell Res. 211 (2): 391–9. doi:10.1006/excr.1994.1103. PMID 8143788.
• Kárpáti S, Amagai M, Prussick R; et al. (1993). "Pemphigus vulgaris antigen, a desmoglein type of cadherin, is localized within keratinocyte desmosomes". J. Cell Biol. 122 (2): 409–15. doi:10.1083/jcb.122.2.409. PMC 2119642. PMID 8320263.
• Silos SA, Tamai K, Li K; et al. (1996). "Cloning of the gene for human pemphigus vulgaris antigen (desmoglein 3), a desmosomal cadherin. Characterization of the promoter region and identification of a keratinocyte-specific cis-element". J. Biol. Chem. 271 (29): 17504–11. doi:10.1074/jbc.271.29.17504. PMID 8663392.
• Marsden MD, Collins JE, Greenwood MD; et al. (1997). "Cloning and transcriptional analysis of the promoter of the human type 2 desmocollin gene (DSC2)". Gene 186 (2): 237–47. doi:10.1016/S0378-1119(96)00715-9. PMID 9074502.
• Adams MJ, Reichel MB, King IA; et al. (1998). "Characterization of the regulatory regions in the human desmoglein genes encoding the pemphigus foliaceous and pemphigus vulgaris antigens". Biochem. J. 329. ( Pt 1): 165–74. PMC 1219028. PMID 9405290.
• Shirakata Y, Amagai M, Hanakawa Y; et al. (1998). "Lack of mucosal involvement in pemphigus foliaceus may be due to low expression of desmoglein 1". J. Invest. Dermatol. 110 (1): 76–8. doi:10.1046/j.1523-1747.1998.00085.x. PMID 9424092.
• Amagai M, Nishikawa T, Nousari HC; et al. (1998). "Antibodies against desmoglein 3 (pemphigus vulgaris antigen) are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice". J. Clin. Invest. 102 (4): 775–82. doi:10.1172/JCI3647. PMC 508940. PMID 9710446.
• Ishikawa H, Li K, Tamai K; et al. (2001). "Cloning of the mouse desmoglein 3 gene (Dsg3): interspecies conservation within the cadherin superfamily". Exp. Dermatol. 9 (4): 229–39. doi:10.1034/j.1600-0625.2000.009004229.x. PMID 10949543.
• Czerwenka KF, Manavi M, Hosmann J; et al. (2001). "Comparative analysis of two-dimensional protein patterns in malignant and normal human breast tissue". Cancer Detect. Prev. 25 (3): 268–79. PMID 11425269.
• Weiske J, Schöneberg T, Schröder W; et al. (2001). "The fate of desmosomal proteins in apoptotic cells". J. Biol. Chem. 276 (44): 41175–81. doi:10.1074/jbc.M105769200. PMID 11500511.
• Andl CD, Stanley JR (2001). "Central role of the plakoglobin-binding domain for desmoglein 3 incorporation into desmosomes". J. Invest. Dermatol. 117 (5): 1068–74. doi:10.1046/j.0022-202x.2001.01528.x. PMID 11710914.
• Merritt AJ, Berika MY, Zhai W; et al. (2002). "Suprabasal desmoglein 3 expression in the epidermis of transgenic mice results in hyperproliferation and abnormal differentiation". Mol. Cell. Biol. 22 (16): 5846–58. doi:10.1128/MCB.22.16.5846-5858.2002. PMC 133994. PMID 12138195.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hanakawa Y, Amagai M, Shirakata Y; et al. (2003). "Differential effects of desmoglein 1 and desmoglein 3 on desmosome formation". J. Invest. Dermatol. 119 (6): 1231–6. doi:10.1046/j.1523-1747.2002.19648.x. PMID 12485422.
• Veldman C, Stauber A, Wassmuth R; et al. (2003). "Dichotomy of autoreactive Th1 and Th2 cell responses to desmoglein 3 in patients with pemphigus vulgaris (PV) and healthy carriers of PV-associated HLA class II alleles". J. Immunol. 170 (1): 635–42. doi:10.4049/jimmunol.170.1.635. PMID 12496453.
• Posthaus H, Dubois CM, Müller E (2003). "Novel insights into cadherin processing by subtilisin-like convertases". FEBS Lett. 536 (1-3): 203–8. doi:10.1016/S0014-5793(02)03897-8. PMID 12586364.