GSK-789,472

GSK-789,472

Systematic (IUPAC) name
4,5-dihydro-1-phenyl-3-(piperidin-2-yl)methylimidazol-2(1H)one
Identifiers
ATC code	None
Chemical data
Formula	C15H21N3O
Molar mass	259.168 g/mol
SMILES O=C1N(CC2NCCCC2)CCN1C3=CC=CC=C3
(verify)

GSK-789,472 is a drug which acts as both a potent and selective partial agonist at the dopamine receptor D₂, as well as an antagonist at the related D₃ subtype, but with good selectivity over D₄ and other unrelated receptors.^[1]

References

1. Holmes IP, Blunt RJ, Lorthioir OE, Blowers SM, Gribble A, Payne AH, Stansfield IG, Wood M, Woollard PM, Reavill C, Howes CM, Micheli F, Di Fabio R, Donati D, Terreni S, Hamprecht D, Arista L, Worby A, Watson SP (March 2010). "The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure". Bioorganic & Medicinal Chemistry Letters 20 (6): 2013–6. doi:10.1016/j.bmcl.2010.01.090. PMID 20153647.