Homoquinolinic acid
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| Systematic (IUPAC) name | |
|---|---|
|
3-(Carboxymethyl)-2-pyridinecarboxylic acid | |
| Identifiers | |
| CAS Number | 490-75-5 |
| ATC code | None |
| PubChem | CID 3080554 |
| ChemSpider | 2338312 |
| Synonyms | Homoquinolinate |
| Chemical data | |
| Formula | C8H7NO4 |
| Molar mass | 181.145 g/mol |
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Homoquinolinic acid (HQA) is a potent excitotoxin[1] which is a conformationally-restricted analogue of N-methyl-D-aspartate (NMDA) and a partial agonist of the main/glutamate site of the NMDA receptor, with some selectivity for NR2B subunit-containing receptors.[2][3][4] It is approximately equipotent to NMDA and about five times more potent than quinolinic acid as an agonist of the NMDA receptor.[5] HQA has also been found to label a novel, yet uncharacterized binding site, which can be distinguished from the NMDA receptor with the use of 2-carboxy-3-carboxymethylquinoline (CCMQ), a selective ligand of the uncharacterized site.[6]
See also
References
- ↑ T. W. Stone (1989). Quinolinic acid and the kynurenines. CRC Press. ISBN 978-0-8493-6592-8.
- ↑ Ian P. Stolerman (31 July 2010). Encyclopedia of Psychopharmacology. Springer Science & Business Media. pp. 511–. ISBN 978-3-540-68698-9.
- ↑ Prado De Carvalho, Lia; Bochet, Pascal; Rossier, Jean (1996). "THE ENDOGENEOUS AGONIST QUINOLINIC ACID AND THE NON ENDOGENOUS HOMOQUINOLINIC ACID DISCRIMINATE BETWEEN NMDAR2 RECEPTOR SUBUNITS". Neurochemistry International 28 (4): 445–452. doi:10.1016/0197-0186(95)00091-7. ISSN 0197-0186.
- ↑ Thomas L. Lemke; David A. Williams (24 January 2012). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. pp. 404–. ISBN 978-1-60913-345-0.
- ↑ C.S.A. Neurosciences Abstracts. Cambridge Scientific Abstracts. 1984.
- ↑ Jan Egebjerg; Arne Schousboe; Povl Krogsgaard-Larsen (4 October 2001). Glutamate and GABA Receptors and Transporters: Structure, Function and Pharmacology. CRC Press. pp. 73–. ISBN 978-0-203-29938-8.
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