RhoGEF domain

RhoGEF domain

Structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein.[1]
Identifiers
Symbol RhoGEF
Pfam PF00621
InterPro IPR000219
SMART RhoGEF
SCOP 1dbh
SUPERFAMILY 1dbh
OPM protein 1xd4

RhoGEF domain is a structural domain of guanine nucleotide exchange factors for Rho/Rac/Cdc42-like GTPases. It is also called "Dbl-homologous" (DH) domain.

Subfamilies

Human proteins containing this domain

ABR; AKAP13; ARHGEF1; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF15; ARHGEF16; ARHGEF17; ARHGEF18; ARHGEF19; ARHGEF2; ARHGEF3; ARHGEF4; ARHGEF5; ARHGEF6; ARHGEF7; ARHGEF9; ASEF2; BCR; C9orf100; DEPDC2; DNMBP; ECT2; FARP1; FARP2; FGD1; FGD2; FGD3; FGD4; FGD5; FGD6; GEFT; ITSN1; ITSN2; KALRN; LFDH; MCF2; MCF2L; MCF2L2; NET1; NGEF; OBSCN; PLEKHG1; PLEKHG2; PLEKHG3; PLEKHG4; PLEKHG5; PLEKHG6; PREX1; RASGRF1; SGEF; SOS1; SOS2; SPATA13; TIAM1; TIAM2; TRIO; VAV1; VAV2; VAV3;

Notes

  1. Soisson, S.; Nimnual, A.; Uy, M.; Bar-Sagi, D.; Kuriyan, J. (1998). "Crystal Structure of the Dbl and Pleckstrin Homology Domains from the Human Son of Sevenless Protein". Cell 95 (2): 259–268. doi:10.1016/S0092-8674(00)81756-0. PMID 9790532.

References

This article is issued from Wikipedia - version of the Wednesday, January 27, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.