UBE2C

Ubiquitin-conjugating enzyme E2C
PDB rendering based on 1i7k.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1I7K​, 4YII​
Identifiers
Symbols	UBE2C ; UBCH10; dJ447F3.2
External IDs	OMIM: 605574 MGI: 1915862 HomoloGene: 5096 GeneCards: UBE2C Gene
EC number	6.3.2.19
Gene ontology Molecular function • ubiquitin-protein transferase activity • protein binding • ATP binding • ligase activity • ubiquitin protein ligase binding • ubiquitin protein ligase activity • ubiquitin conjugating enzyme activity Cellular component • nucleus • nucleoplasm • anaphase-promoting complex • cytoplasm • cytosol Biological process • mitotic cell cycle • ubiquitin-dependent protein catabolic process • mitotic spindle assembly checkpoint • negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation • exit from mitosis • free ubiquitin chain polymerization • protein ubiquitination • regulation of mitotic metaphase/anaphase transition • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process • positive regulation of exit from mitosis • cell division • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • activation of anaphase-promoting complex activity • protein K48-linked ubiquitination • protein K11-linked ubiquitination Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11065	68612
Ensembl	ENSG00000175063	ENSMUSG00000001403
UniProt	O00762	Q9D1C1
RefSeq (mRNA)	NM_001281741	NM_026785
RefSeq (protein)	NP_001268670	NP_081061
Location (UCSC)	Chr 20: 45.81 – 45.82 Mb	Chr 2: 164.77 – 164.78 Mb
PubMed search

Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.^[1][2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.^[2]

References

1. Townsley FM, Aristarkhov A, Beck S, Hershko A, Ruderman JV (Apr 1997). "Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase". Proc Natl Acad Sci U S A 94 (6): 2362–7. doi:10.1073/pnas.94.6.2362. PMC 20093. PMID 9122200.
2. "Entrez Gene: UBE2C ubiquitin-conjugating enzyme E2C".

Further reading

• Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.
• Tang Z, Li B, Bharadwaj R, et al. (2002). "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex". Mol. Biol. Cell 12 (12): 3839–51. doi:10.1091/mbc.12.12.3839. PMC 60759. PMID 11739784.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Lin Y, Hwang WC, Basavappa R (2002). "Structural and functional analysis of the human mitotic-specific ubiquitin-conjugating enzyme, UbcH10". J. Biol. Chem. 277 (24): 21913–21. doi:10.1074/jbc.M109398200. PMID 11927573.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Okamoto Y, Ozaki T, Miyazaki K, et al. (2003). "UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme". Cancer Res. 63 (14): 4167–73. PMID 12874022.
• Chuang TH, Ulevitch RJ (2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors". Nat. Immunol. 5 (5): 495–502. doi:10.1038/ni1066. PMID 15107846.
• Wagner KW, Sapinoso LM, El-Rifai W, et al. (2004). "Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin". Oncogene 23 (39): 6621–9. doi:10.1038/sj.onc.1207861. PMID 15208666.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Le XF, Lammayot A, Gold D, et al. (2005). "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling". J. Biol. Chem. 280 (3): 2092–104. doi:10.1074/jbc.M403080200. PMID 15504738.
• Pallante P, Berlingieri MT, Troncone G, et al. (2005). "UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas". Br. J. Cancer 93 (4): 464–71. doi:10.1038/sj.bjc.6602721. PMC 2361574. PMID 16106252.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Takahashi Y, Ishii Y, Nishida Y, et al. (2006). "Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH". Cancer Genet. Cytogenet. 168 (1): 30–5. doi:10.1016/j.cancergencyto.2005.12.011. PMID 16772118.
• Lin J, Raoof DA, Wang Z, et al. (2007). "Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma". Neoplasia 8 (12): 1062–71. doi:10.1593/neo.05832. PMC 1783715. PMID 17217624.
• Ieta K, Ojima E, Tanaka F, et al. (2007). "Identification of overexpressed genes in hepatocellular carcinoma, with special reference to ubiquitin-conjugating enzyme E2C gene expression". Int. J. Cancer 121 (1): 33–8. doi:10.1002/ijc.22605. PMID 17354233.