Atamestane

Atamestane

Systematic (IUPAC) name
(8R,9S,10S,13S,14S)-1,10,13-Trimethyl-7,8,9,11,12, 14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-dione
Clinical data
Legal status
Legal status	UK: Class C
Identifiers
CAS Number	96301-34-7
ATC code	none
PubChem	CID 57050
ChemSpider	51438
UNII	62GA3K28B6
ChEMBL	CHEMBL2105987
Chemical data
Formula	C20H26O2
Molar mass	298.419 g/mol
SMILES O=C\1/C=C(/C)[C@]4(C(=C/1)/CC[C@@H]3[C@@H]4CC[C@@]2(C(=O)CC[C@H]23)C)C
InChI InChI=1S/C20H26O2/c1-12-10-14(21)11-13-4-5-15-16-6-7-18(22)19(16,2)9-8-17(15)20(12,13)3/h10-11,15-17H,4-9H2,1-3H3/t15-,16-,17-,19-,20-/m0/s1 Key:PEPMWUSGRKINHX-TXTPUJOMSA-N
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Atamestane is an aromatase inhibitor that is being studied in the treatment of cancer. Atamestane blocks the production of the hormone estrogen in the body.

It is selective.^[1]

References

1. el Etreby MF (March 1993). "Atamestane: an aromatase inhibitor for the treatment of benign prostatic hyperplasia. A short review". J. Steroid Biochem. Mol. Biol. 44 (4-6): 565–72. doi:10.1016/0960-0760(93)90260-4. PMID 7682838.

External links

• Atamestane entry in the public domain NCI Dictionary of Cancer Terms

 This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".