Chromosomal rearrangement

In genetics, a chromosomal rearrangement is a type of chromosome abnormality involving a change in the structure of the native chromosome.[1] Such changes may involve several different classes of events, like deletions, duplications, inversions, and translocations. Usually, these events are caused by a breakage in the DNA double helices at two different locations, followed by a rejoining of the broken ends to produce a new chromosomal arrangement of genes, different from the gene order of the chromosomes before they were broken.[2] Structural chromosomal abnormalities are estimated to occur in around 0.5% of newborn infants.[3]

Some chromosomal regions are more prone to rearrangement than others and thus are the source of genetic diseases and cancer. This instability is usually due to the propensity of these regions to misalign during DNA repair, exacerbated by defects of the appearance of replication proteins (like FEN1 or Pol δ) that ubiquitously affect the integrity of the genome.[4]

Complex chromosomal rearrangements (CCR) are rarely seen in the general population and are defined as structural chromosomal rearrangements with at least three breakpoints with exchange of genetic material between two or more chromosomes.[5] Some forms of campomelic dysplasia, for example, result from CCRs.

It is possible that speciation frequently occurs when a population becomes fixed for one or more chromosomal rearrangements that reduce fitness when they are heterozygous. This theory is lacking in theoretical support because mutations that cause a large reduction in fitness can only be fixed through genetic drift in small, inbred populations, and the effects of chromosomal rearrangements on fitness are unpredictable and vary greatly in plant and animal species. However, a potential mechanism that could promote speciation is that rearrangements reduce gene flow more by suppressing recombination (and extending the effects of linked isolation genes) than by reducing fitness.[6]

References

  1. ↑ UniProt. Keyword Chromosomal rearrangement. Accessed 26 Dec 2012.
  2. ↑ Griffiths, Anthony J.F.; Gelbart, William M.; Miller, Jeffrey H.; Lewontin., Richard C. (1999). "Chromosomal Rearrangements id=NBK21367". Modern Genetic Analysis. New York: W. H. Freeman. ISBN 0-7167-3118-5.
  3. ↑ Jacobs PA, Browne C, Gregson N, Joyce C, White H (February 1992). "Estimates of the frequency of chromosome abnormalities detectable in unselected newborns using moderate levels of banding". J. Med. Genet. 29 (2): 103–8. doi:10.1136/jmg.29.2.103. PMC 1015848. PMID 1613759.
  4. ↑ Piazza A, Serero A, Boulé JB, Legoix-Né P, Lopes J, Nicolas A (2012). "Stimulation of gross chromosomal rearrangements by the human CEB1 and CEB25 minisatellites in Saccharomyces cerevisiae depends on G-quadruplexes or Cdc13". PLoS Genet. 8 (11): e1003033. doi:10.1371/journal.pgen.1003033. PMC 3486850. PMID 23133402.
  5. ↑ Karadeniz N, Mrasek K, Weise A (2008). "Further delineation of complex chromosomal rearrangements in fertile male using multicolor banding". Mol Cytogenet 1: 17. doi:10.1186/1755-8166-1-17. PMC 2531127. PMID 18687140.
  6. ↑ Rieseberg LH (2001). "Chromosomal rearrangements and speciation". Trends Ecol Evol. 16 (7): 351–358. PMID 11403867.
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