Licarbazepine
 | |
| Systematic (IUPAC) name | |
|---|---|
|
(R,S)-10,11-dihydro-10-hydroxy-5H-Dibenz[b,f]azepine-5-carboxamide | |
| Identifiers | |
| CAS Number | 29331-92-8 |
| ATC code | None |
| PubChem | CID 114709 |
| ChemSpider | 102704 |
| UNII |
XFX1A5KJ3V  |
| ChEMBL | CHEMBL1067 |
| Chemical data | |
| Formula | C15H14N2O2 |
| Molar mass | 254.28 g/mol |
| Specific rotation | racemic |
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Licarbazepine is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects that is related to oxcarbazepine.[1] It is an active metabolite of oxcarbazepine.[1][2] In addition, an isomer of licarbazepine, eslicarbazepine ((S)-(+)-licarbazepine), is an active metabolite of eslicarbazepine acetate.[1][2] Oxcarbazepine and eslicarbazepine acetate are inactive on their own, and behave instead as prodrugs to licarbazepine and eslicarbazepine, respectively, to produce their therapeutic effects.[1][2]
References
- 1 2 3 4 Singh RP, Asconapé JJ (2011). "A review of eslicarbazepine acetate for the adjunctive treatment of partial-onset epilepsy". J Cent Nerv Syst Dis 3: 179–87. doi:10.4137/JCNSD.S4888. PMC 3663619. PMID 23861647.
- 1 2 3 Bialer M, Soares-da-Silva P (June 2012). "Pharmacokinetics and drug interactions of eslicarbazepine acetate". Epilepsia 53 (6): 935–46. doi:10.1111/j.1528-1167.2012.03519.x. PMID 22612290.
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