GUCY2F

Guanylate cyclase 2F, retinal
Identifiers
Symbols GUCY2F ; CYGF; GC-F; GUC2DL; GUC2F; RETGC-2; ROS-GC2
External IDs OMIM: 300041 HomoloGene: 37491 GeneCards: GUCY2F Gene
EC number 4.6.1.2
Orthologs
Species Human Mouse
Entrez 2986 245650
Ensembl ENSG00000101890 ENSMUSG00000042282
UniProt P51841 Q5SDA5
RefSeq (mRNA) NM_001522 NM_001007576
RefSeq (protein) NP_001513 NP_001007577
Location (UCSC) Chr X:
109.37 – 109.48 Mb
Chr X:
142.08 – 142.2 Mb
PubMed search

Retinal guanylyl cyclase 2 also known as guanylate cyclase F (GUCY2F) is a protein that in humans is encoded by the GUCY2F gene.[1]

Function

The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein.[1]

Clinical significance

Defects in this gene may be a cause of X-linked retinitis pigmentosa.[1]

References

Further Reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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