Haloprogin

"Polik" redirects here. For other uses, see Polik (disambiguation).

Haloprogin
Systematic (IUPAC) name

1,2,4-trichloro-5-[(3-iodoprop-2-yn-1-yl)oxy]benzene
Clinical data
Routes of administration	Topical
Legal status	Not available in U.S.
Identifiers
CAS Number	777-11-7^Y
ATC code	D01AE11 (WHO)
PubChem	CID 3561
DrugBank	DB00793^Y
ChemSpider	3440^Y
UNII	AIU7053OWL^Y
KEGG	D00339^Y
ChEMBL	CHEMBL1289^Y
Chemical data
Formula	C₉H₄Cl₃IO
Molar mass	361.39 g/mol
SMILES Clc1cc(OCC#CI)c(Cl)cc1Cl
InChI InChI=1S/C9H4Cl3IO/c10-6-4-8(12)9(5-7(6)11)14-3-1-2-13/h4-5H,3H2^Y Key:CTETYYAZBPJBHE-UHFFFAOYSA-N^Y
Physical data
Melting point	113.5 °C (236.3 °F)
Solubility in water	insoluble mg/mL (20 °C)
(verify)

Haloprogin is an antifungal drug used to treat athlete's foot and other fungal infections. It is marketed in creams under the trade names Halotex, Mycanden, Mycilan, and Polik.

Action

Haloprogin was previously used in 1% topical creams as an antifungal agent. It was marketed over the counter primarily to treat tinea infections of the skin. The mechanism of action is unknown.^[1]

Haloprogin had a high incidence of side effects including: irritation, burning, vesiculation (blisters), scaling, and itching. It has since been discontinued due to the emergence of more modern antifungals with fewer side effects.^[2]

References

↑ "Haloprogin". Drugs@FDA. Food and Drug Administration. Retrieved 2007-02-17.
↑ "Haloprogin". DrugBank. University of Alberta. Nov 6, 2006. Retrieved 2007-02-17.

Antifungals (D01 and J02)

Wall/
membrane

Ergosterol
inhibitors

Azoles
(lanosterol 14
alpha-demethylase inhibitors)

Imidazoles	Topical: bifonazole^‡ chlormidazole^‡ croconazole^‡ fenticonazole^‡ isoconazole^‡ luliconazole neticonazole^‡ omoconazole^‡ butoconazole clotrimazole^# econazole ketoconazole miconazole^# oxiconazole sertaconazole sulconazole tioconazole Systemic: ketoconazole

Triazoles	Topical: fluconazole^#, fosfluconazole efinaconazole terconazole Systemic: hexaconazole^‡ isavuconazole fluconazole^# itraconazole posaconazole voriconazole Unknown: albaconazole^‡

Thiazoles	Topical: abafungin^‡

Polyene antimycotics
(ergosterol binding)

Topical: hamycin^‡
natamycin
nystatin^#
Systemic: amphotericin B^#, hamycin^‡

Allylamines
(squalene monooxygenase
inhibitors)

Topical: amorolfine^‡
butenafine
naftifine
terbinafine
Systemic: terbinafine

β-glucan synthase
inhibitors

Intracellular

Pyrimidine analogues/ thymidylate synthase inhibitors	flucytosine^#

Mitotic inhibitors	griseofulvin^#

Aminoacyl tRNA synthetase inhibitors	tavaborole

Others

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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