TRNA-intron endonuclease
tRNA-intron lyase (EC 4.6.1.16, tRNA intron endonuclease, transfer ribonucleate intron endoribonuclease, tRNA splicing endonuclease, splicing endonuclease, tRNATRPintron endonuclease, transfer splicing endonuclease) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction
- pre-tRNA a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus
This enzyme catalyses the final stage in the maturation of tRNA molecules. Its systematic name is pretRNA lyase (intron-removing; cyclic-2',3'-phosphate-forming).
References
- ↑ Attardi, D.G., Margarit, I. and Tocchini-Valentini, G.P. (1985). "Structural alterations in mutant precursors of the yeast tRNALeu3 gene which behave as defective substrates for a highly purified splicing endoribonuclease". EMBO J. 4 (12): 3289–3297. PMC 554656. PMID 3937725.
- ↑ Peebles, C.L., Gegenheimer, P. and Abelson, J. (1983). "Precise excision of intervening sequences from precursor tRNAs by a membrane-associated yeast endonuclease". Cell 32 (2): 525–536. doi:10.1016/0092-8674(83)90472-5. PMID 6186398.
- ↑ Thompson, L.D., Brandon, L.D., Nieuwlandt, D.T. and Daniels, C.J. (1989). "Transfer RNA intron processing in the halophilic archaebacteria". Can. J. Microbiol. 35 (1): 36–42. doi:10.1139/m89-006. PMID 2470486.
- ↑ Thompson, L.D. and Daniels, C.J. (1988). "A tRNA(Trp) intron endonuclease from Halobacterium volcanii. Unique substrate recognition properties". J. Biol. Chem. 263 (34): 17951–17959. PMID 3192521.
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