Thialbarbital

Thialbarbital

Systematic (IUPAC) name
5-allyl-5-cyclohex-2-en-1-yl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Clinical data
Legal status	CA: Schedule IV
Identifiers
CAS Number	3546-29-0
ATC code	none
PubChem	CID 3032306
ChemSpider	2297316
UNII	ENV72C33QD
ChEMBL	CHEMBL2104657
Synonyms	Kemithal, 5-(1-cyclohex-2-enyl)-5-prop-2-enyl-2-sulfanylidene-1,3-diazinane-4,6-dione
Chemical data
Formula	C13H16N2O2S
Molar mass	264.344 g/mol
SMILES O=C1NC(=S)NC(=O)C1(C2/C=C\CCC2)C\C=C
InChI InChI=1S/C13H16N2O2S/c1-2-8-13(9-6-4-3-5-7-9)10(16)14-12(18)15-11(13)17/h2,4,6,9H,1,3,5,7-8H2,(H2,14,15,16,17,18) Key:PXLVRFQEBVNJOH-UHFFFAOYSA-N
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Thialbarbital (Intranarcon) is a barbiturate derivative invented in the 1960s. It has sedative effects, and was used primarily for induction in surgical anaesthesia. ^[1] Thialbarbital is short acting and has less of a tendency to induce respiratory depression than other barbiturate derivatives such as pentobarbital. ^[2]

Synthesis

Thialbarbital synthesis: Volwiler, Tabern, U.S. Patent 2,153,730 (1939 to Abbott)

See also

• Thiamylal

References

1. Golovchinsky VB, Plehotkina SI. Difference in the sensitivity of the cerebral cortex and midbrain reticular formation to the action of diethylether and thialbarbital. Brain Research. 1971 Jul 9;30(1):37-47.
2. Bercovitz AB, Godke RA, Biellier HV, Short CE. Surgical anesthesia in turkeys with thialbarbital sodium. American Journal of Veterinary Research. 1975 Mar;36(3):301-2.