3-Hydroxyphenazepam
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| Systematic (IUPAC) name | |
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7-Bromo-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one | |
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| Identifiers | |
| CAS Number | 70030-11-4 |
| ATC code | None |
| PubChem | CID 125820 |
| ChemSpider | 111897 |
| Chemical data | |
| Formula | C15H10BrClN2O2 |
| Molar mass | 365.609 g/mol |
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3-Hydroxyphenazepam is a benzodiazepine with hypnotic, sedative, anxiolytic, and anticonvulsant properties.[1] It is an active metabolite of phenazepam,[1][2] as well as the active metabolite of the benzodiazepine prodrug cinazepam.[3] Relative to phenazepam, 3-hydroxyphenazepam has diminished myorelaxant properties, but is about equivalent in most other regards.[1] Like other benzodiazepines, 3-hydroxyphenazepam behaves as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor.[4][5] It has been sold online as a designer drug.
See also
References
- 1 2 3 Artur Viktorovich Valʹdman (31 May 1986). Drug dependence and emotional behavior: neurophysiological and neurochemical approaches. Consultants Bureau. ISBN 978-0-306-10984-3.
- ↑ Lukasz Komsta; Monika Waksmundzka-Hajnos; Joseph Sherma (20 December 2013). Thin Layer Chromatography in Drug Analysis. CRC Press. pp. 299–. ISBN 978-1-4665-0715-9.
- ↑ Schukin SI, Zinkovsky VG, Zhuk OV (2011). "Elimination kinetics of the novel prodrug cinazepam possessing psychotropic activity in mice" (PDF). Pharmacol Rep 63 (5): 1093–100. PMID 22180351.
- ↑ Kopanitsa, M. V.; Zbarska, S. M.; Boychuk, Ya. A.; Krishtal, O. A. (2000). "Modulation of GABA-activated currents by phenazepam and its metabolites in isolated rat purkinje neurons". Neurophysiology 32 (3): 192–192. doi:10.1007/BF02506568. ISSN 0090-2977.
- ↑ Golovenko, N. Ya; Larionov, V. B. (2014). "Pharmacodynamical and Neuroreceptor Analysis of the Permeability of the Blood-Brain Barrier for Derivatives of 1,4-Benzodiazepine". Neurophysiology 46 (3): 199–205. doi:10.1007/s11062-014-9429-2. ISSN 0090-2977.
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