CCP110

Centriolar coiled coil protein 110kDa
Identifiers
Symbols	CCP110 ; CP110; Cep110
External IDs	OMIM: 609544 MGI: 2141942 HomoloGene: 8810 GeneCards: CCP110 Gene
Gene ontology Molecular function • protein binding Cellular component • centrosome • centriole • cytosol • protein complex Biological process • G2/M transition of mitotic cell cycle • mitotic cell cycle • organelle organization • centriole replication • cell projection organization • regulation of cytokinesis • centrosome duplication Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9738	101565
Ensembl	ENSG00000103540	ENSMUSG00000033904
UniProt	O43303	Q7TSH4
RefSeq (mRNA)	NM_001199022	NM_182995
RefSeq (protein)	NP_001185951	NP_892040
Location (UCSC)	Chr 16: 19.52 – 19.55 Mb	Chr 7: 118.71 – 118.74 Mb
PubMed search

Centriolar coiled-coil protein of 110 kDa also known as centrosomal protein of 110 kDa or CP110 is a protein that in humans is encoded by the CCP110 gene. It is a cell cycle-dependent CDK substrate and regulates centrosome duplication.^[1][2] CP110 suppresses a cilia assembly program.^[3]

References

1. Chen Z, Indjeian VB, McManus M, Wang L, Dynlacht BD (September 2002). "CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells". Dev. Cell 3 (3): 339–50. doi:10.1016/S1534-5807(02)00258-7. PMID 12361598.
2. Li J, D'Angiolella V, Seeley ES, Kim S, Kobayashi T, Fu W, Campos EI, Pagano M, Dynlacht BD (March 2013). "USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110". Nature 495 (7440): 255–9. doi:10.1038/nature11941. PMID 23486064.
3. Spektor A, Tsang WY, Khoo D, Dynlacht BD (August 2007). "Cep97 and CP110 suppress a cilia assembly program". Cell 130 (4): 678–90. doi:10.1016/j.cell.2007.06.027. PMID 17719545.

Further reading

• Ishikawa K, Nagase T, Nakajima D; et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
• Loftus BJ, Kim UJ, Sneddon VP; et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.". Genomics 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Andersen JS, Wilkinson CJ, Mayor T; et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling.". Nature 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zou C, Li J, Bai Y; et al. (2006). "Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication.". J. Cell Biol. 171 (3): 437–45. doi:10.1083/jcb.200506185. PMC 2171251. PMID 16275750.
• Tsang WY, Spektor A, Luciano DJ; et al. (2006). "CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability.". Mol. Biol. Cell 17 (8): 3423–34. doi:10.1091/mbc.E06-04-0371. PMC 1525247. PMID 16760425.
• Beausoleil SA, Villén J, Gerber SA; et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Pearson CG, Culver BP, Winey M (2007). "Centrioles want to move out and make cilia.". Dev. Cell 13 (3): 319–21. doi:10.1016/j.devcel.2007.08.007. PMID 17765674.