CEP350

Centrosomal protein 350kDa
PDB rendering based on 2coz.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2COZ​
Identifiers
Symbols	CEP350 ; CAP350; GM133
External IDs	MGI: 1921331 HomoloGene: 8879 GeneCards: CEP350 Gene
Gene ontology Molecular function • protein binding • microtubule binding Cellular component • nucleoplasm • cytoplasm • centrosome • spindle • membrane Biological process • microtubule anchoring Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9857	74081
Ensembl	ENSG00000135837	ENSMUSG00000033671
UniProt	Q5VT06	E9Q309
RefSeq (mRNA)	NM_014810	NM_001039184
RefSeq (protein)	NP_055625	NP_001034273
Location (UCSC)	Chr 1: 179.95 – 180.11 Mb	Chr 1: 155.84 – 155.97 Mb
PubMed search

Centrosome-associated protein 350 is a protein that in humans is encoded by the CEP350 gene.^[1][2][3]

CEP350 is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. It primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. CEP350 is required to anchor microtubules at the centrosome. Furthermore, it increases the stability of growing centrioles.^[4]

It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined.^[3]

References

1. Yan X, Habedanck R, Nigg EA (Jan 2006). "A Complex of Two Centrosomal Proteins, CAP350 and FOP, Cooperates with EB1 in Microtubule Anchoring". Mol Biol Cell 17 (2): 634–44. doi:10.1091/mbc.E05-08-0810. PMC 1356575. PMID 16314388.
2. Patel H, Truant R, Rachubinski RA, Capone JP (Dec 2004). "Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome-associated protein CAP350". J Cell Sci 118 (Pt 1): 175–86. doi:10.1242/jcs.01600. PMID 15615782.
3. "Entrez Gene: CEP350 centrosomal protein 350kDa".
4. Le Clech, M (2008). "Role of CAP350 in centriolar tubule stability and centriole assembly.". PLoS ONE 3 (12): e3855. doi:10.1371/journal.pone.0003855. PMC 2586089. PMID 19052644.

Further reading

• Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Yu W, Andersson B, Worley KC; et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Seki N, Ohira M, Nagase T; et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
• Makalowska I, Sood R, Faruque MU; et al. (2002). "Identification of six novel genes by experimental validation of GeneMachine predicted genes". Gene 284 (1–2): 203–13. doi:10.1016/S0378-1119(01)00897-6. PMID 11891061.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Andersen JS, Wilkinson CJ, Mayor T; et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Oh JH, Yang JO, Hahn Y; et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Nousiainen M, Silljé HH, Sauer G; et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Hoppeler-Lebel A, Celati C, Bellett G; et al. (2007). "Centrosomal CAP350 protein stabilises microtubules associated with the Golgi complex". J. Cell. Sci. 120 (Pt 18): 3299–308. doi:10.1242/jcs.013102. PMID 17878239.