CEP192

Centrosomal protein 192kDa
Identifiers
Symbols	CEP192 ; PPP1R62
External IDs	OMIM: 616426 HomoloGene: 73526 GeneCards: CEP192 Gene
Gene ontology Molecular function • protein binding • phosphatase binding Cellular component • pericentriolar material • cytoplasm • centrosome • centriole • cytosol Biological process • G2/M transition of mitotic cell cycle • mitotic cell cycle • organelle organization • negative regulation of phosphatase activity • spindle assembly • centrosome duplication Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55125	70799
Ensembl	ENSG00000101639	ENSMUSG00000024542
UniProt	Q8TEP8	n/a
RefSeq (mRNA)	NM_018069	NM_027556
RefSeq (protein)	NP_115518	NP_081832
Location (UCSC)	Chr 18: 12.99 – 13.13 Mb	Chr 18: 67.8 – 67.89 Mb
PubMed search

Centrosomal protein of 192 kDa, also known as Cep192, is a protein that in humans is encoded by the CEP192 gene.^[1][2] It is the homolog of the C. elegans and D. melanogaster gene SPD-2.^[3]

Cep192 is a major regulator of pericentriolar material recruitment, centrosome maturation, and centriole duplication in mammalian cells.^[3] It stimulates the formation of the scaffolding upon which gamma tubulin ring complexes and other proteins involved in microtubule nucleation and spindle assembly become functional during mitosis.^[4]

References

1. "Entrez Gene: centrosomal protein 192kDa".
2. Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (December 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843.
3. Zhu, F.; Lawo, S.; Bird, A.; Pinchev, D.; Ralph, A.; Richter, C.; Müller-Reichert, T.; Kittler, R.; Hyman, A.; Pelletier, L. (2008). "The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis". Current Biology 18 (2): 136–141. doi:10.1016/j.cub.2007.12.055. PMID 18207742.
4. Gomez-Ferreria, M.; Rath, U.; Buster, D.; Chanda, S.; Caldwell, J.; Rines, D.; Sharp, D. (2007). "Human Cep192 is required for mitotic centrosome and spindle assembly". Current Biology 17 (22): 1960–1966. doi:10.1016/j.cub.2007.10.019. PMID 17980596.

Further reading

• Nagase T, Kikuno R, Nakayama M; et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
• Golsteyn RM, Mundt KE, Fry AM, Nigg EA (1995). "Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function". J. Cell Biol. 129 (6): 1617–28. doi:10.1083/jcb.129.6.1617. PMC 2291169. PMID 7790358.
• Zhu F, Lawo S, Bird A; et al. (2008). "The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis". Curr. Biol. 18 (2): 136–41. doi:10.1016/j.cub.2007.12.055. PMID 18207742.
• Gomez-Ferreria MA, Rath U, Buster DW; et al. (2007). "Human Cep192 is required for mitotic centrosome and spindle assembly". Curr. Biol. 17 (22): 1960–6. doi:10.1016/j.cub.2007.10.019. PMID 17980596.
• Mayor T, Stierhof YD, Tanaka K; et al. (2000). "The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion". J. Cell Biol. 151 (4): 837–46. doi:10.1083/jcb.151.4.837. PMC 2169446. PMID 11076968.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Sowa ME, Bennett EJ, Gygi SP, Harper JW (2009). "Defining the Human Deubiquitinating Enzyme Interaction Landscape". Cell 138 (2): 389–403. doi:10.1016/j.cell.2009.04.042. PMC 2716422. PMID 19615732.
• Takahashi M, Yamagiwa A, Nishimura T; et al. (2002). "Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex". Mol. Biol. Cell 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.
• Casenghi M, Meraldi P, Weinhart U; et al. (2003). "Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation". Dev. Cell 5 (1): 113–25. doi:10.1016/S1534-5807(03)00193-X. PMID 12852856.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Petretti C, Savoian M, Montembault E; et al. (2006). "The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation". EMBO Rep. 7 (4): 418–24. doi:10.1038/sj.embor.7400639. PMC 1456919. PMID 16462731.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967.