Pericentriolar material

Pericentriolar material (PCM, sometimes also called pericentriolar matrix) is an amorphous mass of protein which makes up the part of the animal centrosome that surrounds the two centrioles. The PCM contains proteins responsible for microtubule nucleation and anchoring^[1] including γ-tubulin, pericentrin and ninein.

According to the Gene Ontology, the following human proteins are associated with the PCM :

BBS4, Bardet-Biedl syndrome 4 protein
Lck, Proto-oncogene tyrosine-protein kinase LCK
PCM1, Pericentriolar material 1 protein
TNKS, Tankyrase-1
TNKS2, Tankyrase-2
TUBE1, Tubulin epsilon chain

References

↑ Eddé, B.; Rossier; Le Caer; Desbruyères; Gros; Denoulet (1990). "Posttranslational glutamylation of alpha-tubulin". Science 247 (4938): 83–85. Bibcode:1990Sci...247...83E. doi:10.1126/science.1967194. PMID 1967194.

The centrosome and its components

Centrioles	SASS6 CENPJ CNTROB CEP104 Centrins (CETN1, CETN2 and CETN3) SFI1

Pericentriolar material	BBS4 Lck PCM1 PCNT TNKS TNKS2 Tubulin

other proteins	CCP110 CEP55 CEP57 CEP63 CEP68 CEP70 CEP72 CEP76 CEP78 CEP90 CEP97 CEP120 CEP135 CEP152 CEP164 CEP170 CEP192 CEP215 CEP250 CEP350 CNTRL NIN NINL

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