CEP120

Centrosomal protein 120kDa
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4ICW​, 4ICX​
Identifiers
Symbols	CEP120 ; CCDC100; SRTD13
External IDs	OMIM: 613446 MGI: 2147298 HomoloGene: 27415 GeneCards: CEP120 Gene
Gene ontology Molecular function • protein C-terminus binding Cellular component • cytoplasm • centrosome Biological process • cerebral cortex development • neurogenesis • interkinetic nuclear migration • astral microtubule organization • regulation of protein localization • regulation of microtubule-based process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	153241	225523
Ensembl	ENSG00000168944	ENSMUSG00000048799
UniProt	Q8N960	Q7TSG1
RefSeq (mRNA)	NM_001166226	NM_178686
RefSeq (protein)	NP_001159698	NP_848801
Location (UCSC)	Chr 5: 123.34 – 123.42 Mb	Chr 18: 53.68 – 53.74 Mb
PubMed search

Centrosomal protein of 120 kDa (Cep120), also known as coiled-coil domain-containing protein 100, is a protein that in humans is encoded by the CEP120 gene.^[1][2]

Function

This gene encodes a protein that functions in the microtubule-dependent coupling of the nucleus and the centrosome. A similar protein in mouse plays a role in both interkinetic nuclear migration, which is a characteristic pattern of nuclear movement in neural progenitors, and in neural progenitor self-renewal. Mutations in this gene are predicted to result in neurogenic defects.^[1]

References

1. "Entrez Gene: centrosomal protein 120kDa".
2. Xie Z, Moy LY, Sanada K, Zhou Y, Buchman JJ, Tsai LH (October 2007). "Cep120 and TACCs Control Interkinetic Nuclear Migration and the Neural Progenitor Pool". Neuron 56 (1): 79–93. doi:10.1016/j.neuron.2007.08.026. PMC 2642594. PMID 17920017.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Vasan RS, Glazer NL, Felix JF; et al. (2009). "Genetic Variants Associated With Cardiac Structure and Function: A Meta-analysis and Replication of Genome-wide Association Data". JAMA 302 (2): 168–78. doi:10.1001/jama.2009.978-a. PMC 2975567. PMID 19584346.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Guerrier S, Polleux F (2007). "The ups and downs of neural progenitors: Cep120 and TACCs control interkinetic nuclear migration". Neuron 56 (1): 1–3. doi:10.1016/j.neuron.2007.09.019. PMID 17920006.
• Thorleifsson G, Walters GB, Gudbjartsson DF; et al. (2009). "Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity". Nat. Genet. 41 (1): 18–24. doi:10.1038/ng.274. PMID 19079260.