CEP152

Centrosomal protein 152kDa
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4N7V​
Identifiers
Symbols	CEP152 ; MCPH4; MCPH9; SCKL5
External IDs	OMIM: 613529 MGI: 2139083 HomoloGene: 37159 GeneCards: CEP152 Gene
Gene ontology Molecular function • protein binding • protein kinase binding Cellular component • nucleoplasm • centrosome • cytosol • deuterosome Biological process • G2/M transition of mitotic cell cycle • mitotic cell cycle • organelle organization • centriole replication • cell projection organization • centrosome duplication • de novo centriole assembly Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	22995	99100
Ensembl	ENSG00000103995	ENSMUSG00000068394
UniProt	O94986	A2AUM9
RefSeq (mRNA)	NM_001194998	NM_001081091
RefSeq (protein)	NP_001181927	NP_001074560
Location (UCSC)	Chr 15: 48.71 – 48.81 Mb	Chr 2: 125.56 – 125.63 Mb
PubMed search

Centrosomal protein of 152 kDa, also known as Cep152, is a protein that in humans is encoded by the CEP152 gene.^[1] It is the ortholog of the Drosophila melanogaster gene asterless (asl) and both are required for centriole duplication.^[2]

References

1. "Entrez Gene: centrosomal protein 152kDa".
2. Blachon S, Gopalakrishnan J, Omori Y, Polyanovsky A, Church A, Nicastro D, Malicki J, Avidor-Reiss T (December 2008). "Drosophila asterless and vertebrate Cep152 Are orthologs essential for centriole duplication". Genetics 180 (4): 2081–94. doi:10.1534/genetics.108.095141. PMC 2600943. PMID 18854586.

Further reading

• Nakayama M, Kikuno R, Ohara O (2002). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Nagase T, Ishikawa K, Suyama M; et al. (1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
• Andersen JS, Wilkinson CJ, Mayor T; et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843.
• Golsteyn RM, Mundt KE, Fry AM, Nigg EA (1995). "Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function". J. Cell Biol. 129 (6): 1617–28. doi:10.1083/jcb.129.6.1617. PMC 2291169. PMID 7790358.
• Casenghi M, Meraldi P, Weinhart U; et al. (2003). "Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation". Dev. Cell 5 (1): 113–25. doi:10.1016/S1534-5807(03)00193-X. PMID 12852856.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mayor T, Stierhof YD, Tanaka K; et al. (2000). "The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion". J. Cell Biol. 151 (4): 837–46. doi:10.1083/jcb.151.4.837. PMC 2169446. PMID 11076968.
• Petretti C, Savoian M, Montembault E; et al. (2006). "The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation". EMBO Rep. 7 (4): 418–24. doi:10.1038/sj.embor.7400639. PMC 1456919. PMID 16462731.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Takahashi M, Yamagiwa A, Nishimura T; et al. (2002). "Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex". Mol. Biol. Cell 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.