CEP63

Centrosomal protein 63kDa
Identifiers
Symbols	CEP63 ; SCKL6
External IDs	OMIM: 614724 MGI: 2158560 HomoloGene: 11861 GeneCards: CEP63 Gene
Gene ontology Molecular function • protein binding Cellular component • spindle pole • centrosome • centriole • cytosol Biological process • DNA damage checkpoint • G2/M transition of mitotic cell cycle • mitotic cell cycle • organelle organization • mitotic nuclear division • centriole replication • signal transduction in response to DNA damage • spindle assembly • cell division • de novo centriole assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	80254	28135
Ensembl	ENSG00000182923	ENSMUSG00000032534
UniProt	Q96MT8	Q3UPP8
RefSeq (mRNA)	NM_001042383	NM_001081122
RefSeq (protein)	NP_001035842	NP_001074591
Location (UCSC)	Chr 3: 134.49 – 134.58 Mb	Chr 9: 102.58 – 102.63 Mb
PubMed search

Centrosomal protein of 63 kDa is a protein that in humans is encoded by the CEP63 gene.^[1][2] Several alternatively spliced transcript variants have been found, but their biological validity has not been determined.

Function

This gene encodes a protein with six coiled-coil domains. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells.^[2] Recent computational analysis revealed pathogenic property of L61P point mutation in CEP63 protein that affected its native structural conformation.^[3]

Interactions

CEP63 has been shown to interact with DISC1,^[4] CEP152 and CDK1.^[3]

References

1. Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (Dec 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843.
2. "Entrez Gene: CEP63 centrosomal protein 63kDa".
3. Kumar A, Purohit R (April 2012). "Computational investigation of pathogenic nsSNPs in CEP63 protein". Gene 503 (1): 75–82. doi:10.1016/j.gene.2012.04.032. PMID 22555018.
4. Morris JA, Kandpal G, Ma L, Austin CP (July 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–608. doi:10.1093/hmg/ddg162. PMID 12812986.

Further reading

• Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
• Morris JA, Kandpal G, Ma L, Austin CP (2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–608. doi:10.1093/hmg/ddg162. PMID 12812986.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Buim ME, Soares FA, Sarkis AS, Nagai MA (2005). "The transcripts of SFRP1,CEP63 and EIF4G2 genes are frequently downregulated in transitional cell carcinomas of the bladder". Oncology 69 (6): 445–54. doi:10.1159/000090984. PMID 16410684.