CNTROB

Centrobin, centrosomal BRCA2 interacting protein
Identifiers
Symbols	CNTROB ; LIP8; PP1221
External IDs	OMIM: 611425 MGI: 2443290 HomoloGene: 14205 GeneCards: CNTROB Gene
Gene ontology Molecular function • protein binding • protein domain specific binding Cellular component • cytoplasm • centrosome • centriole Biological process • centriole replication • centrosome separation • mitotic cytokinetic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	116840	216846
Ensembl	ENSG00000170037	ENSMUSG00000032782
UniProt	Q8N137	Q8CB62
RefSeq (mRNA)	NM_001037144	NM_172560
RefSeq (protein)	NP_001032221	NP_766148
Location (UCSC)	Chr 17: 7.93 – 7.95 Mb	Chr 11: 69.3 – 69.32 Mb
PubMed search

Centrobin is a protein that in humans is encoded by the CNTROB gene.^[1] It is a centriole-associated protein that asymmetrically localizes to the daughter centriole, and is required for centriole duplication and cytokinesis.^[2]

References

1. Tchernev, V. T.; Mansfield, T. A.; Giot, L.; Kumar, A. M.; Nandabalan, K.; Li, Y.; Mishra, V. S.; Detter, J. C.; Rothberg, J. M.; Wallace, M. R.; Southwick, F. S.; Kingsmore, S. F. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Molecular medicine (Cambridge, Mass.) 8 (1): 56–64. PMC 2039936. PMID 11984006.
2. Zou, C.; Li, J.; Bai, Y.; Gunning, W.; Wazer, D.; Band, V.; Gao, Q. (2005). "Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication". Journal of Cell Biology 171 (3): 437–445. doi:10.1083/jcb.200506185. PMC 2171251. PMID 16275750.

Further reading

• Jeong Y, Lee J, Kim K; et al. (2007). "Characterization of NIP2/centrobin, a novel substrate of Nek2, and its potential role in microtubule stabilization.". J. Cell. Sci. 120 (Pt 12): 2106–16. doi:10.1242/jcs.03458. PMID 17535851.
• Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Wan D, Gong Y, Qin W; et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.