SFI1

SFI1 centrin binding protein
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2K2I​
Identifiers
Symbols	SFI1 ; PISD; PPP1R139; hSfi1p
External IDs	OMIM: 612765 HomoloGene: 12707 GeneCards: SFI1 Gene
Gene ontology Molecular function • protein binding • phosphatase binding Cellular component • centriole • cytosol Biological process • G2/M transition of mitotic cell cycle • mitotic cell cycle • organelle organization • negative regulation of phosphatase activity Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9814	78887
Ensembl	ENSG00000198089	ENSMUSG00000023764
UniProt	A8K8P3	Q3UZY0
RefSeq (mRNA)	NM_001007467	NM_030207
RefSeq (protein)	NP_001007468	NP_084483
Location (UCSC)	Chr 22: 31.49 – 31.62 Mb	Chr 11: 3.13 – 3.19 Mb
PubMed search

Sfi1 homolog, spindle assembly associated (yeast) is a protein that in humans is encoded by the SFI1 gene. ^[1] It localizes to the centriole, and its S. pombe ortholog has been shown to be involved in spindle pole body duplication.^[2] SFI1 forms a complex with centrin 2.^[3]

References

1. "Entrez Gene: Sfi1 homolog, spindle assembly associated (yeast)". Retrieved 2014-06-25.
2. Elserafy, Menattallah; Šarić, Mirela; Neuner, Annett; Lin, Tien-chen; Zhang, Wanlu; Seybold, Christian; Sivashanmugam, Lavanya; Schiebel, Elmar. "Molecular Mechanisms that Restrict Yeast Centrosome Duplication to One Event per Cell Cycle". Current Biology 24: 1456–1466. doi:10.1016/j.cub.2014.05.032.
3. Martinez-Sanz, J; Kateb, F; Assairi, L; Blouquit, Y; Bodenhausen, G; Abergel, D; Mouawad, L; Craescu, CT (Jan 8, 2010). "Structure, dynamics and thermodynamics of the human centrin 2/hSfi1 complex.". Journal of Molecular Biology 395 (1): 191–204. doi:10.1016/j.jmb.2009.10.041. PMID 19857500.

Further reading

• Martinez-Sanz, J; Kateb, F; Assairi, L; Blouquit, Y; Bodenhausen, G; Abergel, D; Mouawad, L; Craescu, C. T. (2010). "Structure, dynamics and thermodynamics of the human centrin 2/hSfi1 complex". Journal of Molecular Biology 395 (1): 191–204. doi:10.1016/j.jmb.2009.10.041. PMID 19857500.
• Mayor, T; Stierhof, Y. D.; Tanaka, K; Fry, A. M.; Nigg, E. A. (2000). "The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion". The Journal of Cell Biology 151 (4): 837–46. doi:10.1083/jcb.151.4.837. PMC 2169446. PMID 11076968.
• Petretti, C; Savoian, M; Montembault, E; Glover, D. M.; Prigent, C; Giet, R (2006). "The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation". EMBO Reports 7 (4): 418–24. doi:10.1038/sj.embor.7400639. PMC 1456919. PMID 16462731.
• Casenghi, M; Meraldi, P; Weinhart, U; Duncan, P. I.; Körner, R; Nigg, E. A. (2003). "Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation". Developmental Cell 5 (1): 113–25. doi:10.1016/S1534-5807(03)00193-X. PMID 12852856.
• Ajuh, P; Kuster, B; Panov, K; Zomerdijk, J. C.; Mann, M; Lamond, A. I. (2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
• Kilmartin, J. V. (2003). "Sfi1p has conserved centrin-binding sites and an essential function in budding yeast spindle pole body duplication". The Journal of Cell Biology 162 (7): 1211–21. doi:10.1083/jcb.200307064. PMC 2173958. PMID 14504268.
• Hendrickx, A; Beullens, M; Ceulemans, H; Den Abt, T; Van Eynde, A; Nicolaescu, E; Lesage, B; Bollen, M (2009). "Docking motif-guided mapping of the interactome of protein phosphatase-1". Chemistry & Biology 16 (4): 365–71. doi:10.1016/j.chembiol.2009.02.012. PMID 19389623.
• Takahashi, M.; Yamagiwa, A.; Nishimura, T.; Mukai, H.; Ono, Y. (2002). "Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring gamma -Tubulin Ring Complex". Molecular Biology of the Cell 13 (9): 3235–3245. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.
• Golsteyn, R. M.; Mundt, K. E.; Fry, A. M.; Nigg, E. A. (1995). "Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function". The Journal of Cell Biology 129 (6): 1617–28. doi:10.1083/jcb.129.6.1617. PMC 2291169. PMID 7790358.