DNA polymerase alpha subunit 2

Polymerase (DNA directed), alpha 2, accessory subunit
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2KEB​, 4E2I​, 4Y97​
Identifiers
Symbols	POLA2 ; FLJ21662; FLJ37250
External IDs	MGI: 99690 HomoloGene: 48121 GeneCards: POLA2 Gene
Gene ontology Molecular function • molecular_function • DNA binding • DNA-directed DNA polymerase activity • protein heterodimerization activity Cellular component • nucleoplasm • alpha DNA polymerase:primase complex • cytoplasm Biological process • protein import into nucleus, translocation • G1/S transition of mitotic cell cycle • mitotic cell cycle • telomere maintenance via recombination • telomere maintenance • DNA replication • DNA replication initiation • DNA strand elongation involved in DNA replication • telomere maintenance via semi-conservative replication • DNA biosynthetic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23649	18969
Ensembl	ENSG00000014138	ENSMUSG00000024833
UniProt	Q14181	P33611
RefSeq (mRNA)	NM_002689	NM_001164057
RefSeq (protein)	NP_002680	NP_001157529
Location (UCSC)	Chr 11: 65.26 – 65.31 Mb	Chr 19: 5.94 – 5.96 Mb
PubMed search

DNA polymerase alpha subunit 2 is an enzyme that in humans is encoded by the POLA2 gene.^[1][2][3]

Interactions

POLA2 has been shown to interact with PARP1.^[4]

See Also

• DNA Polymerase
• DNA polymerase alpha

References

1. Collins KL, Russo AA, Tseng BY, Kelly TJ (Dec 1993). "The role of the 70 kDa subunit of human DNA polymerase alpha in DNA replication". EMBO J 12 (12): 4555–66. PMC 413886. PMID 8223465.
2. Huang D, Jokela M, Tuusa J, Skog S, Poikonen K, Syväoja JE (Jul 2001). "E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase ɛ B-subunit gene POLE2". Nucleic Acids Res 29 (13): 2810–21. doi:10.1093/nar/29.13.2810. PMC 55767. PMID 11433027.
3. "Entrez Gene: POLA2 polymerase (DNA directed), alpha 2 (70kD subunit)".
4. Dantzer F, Nasheuer HP, Vonesch JL, de Murcia G, Ménissier-de Murcia J (Apr 1998). "Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication". Nucleic Acids Res. 26 (8): 1891–8. doi:10.1093/nar/26.8.1891. PMC 147507. PMID 9518481.

Further reading

• Pollok S, Stoepel J, Bauerschmidt C, Kremmer E, Nasheuer HP (2003). "Regulation of eukaryotic DNA replication at the initiation step". Biochem. Soc. Trans. 31 (Pt 1): 266–9. doi:10.1042/BST0310266. PMID 12546699.
• Nasheuer HP, Moore A, Wahl AF, Wang TS (1991). "Cell cycle-dependent phosphorylation of human DNA polymerase alpha". J. Biol. Chem. 266 (12): 7893–903. PMID 1902230.
• Dantzer F, Nasheuer HP, Vonesch JL, de Murcia G, Ménissier-de Murcia J (1998). "Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication". Nucleic Acids Res. 26 (8): 1891–8. doi:10.1093/nar/26.8.1891. PMC 147507. PMID 9518481.
• Schneider A, Smith RW, Kautz AR, Weisshart K, Grosse F, Nasheuer HP (1998). "Primase activity of human DNA polymerase alpha-primase. Divalent cations stabilize the enzyme activity of the p48 subunit". J. Biol. Chem. 273 (34): 21608–15. doi:10.1074/jbc.273.34.21608. PMID 9705292.
• Taneja P, Gu J, Peng R, Carrick R, Uchiumi F, Ott RD, Gustafson E, Podust VN, Fanning E (2002). "A dominant-negative mutant of human DNA helicase B blocks the onset of chromosomal DNA replication". J. Biol. Chem. 277 (43): 40853–61. doi:10.1074/jbc.M208067200. PMID 12181327.
• Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.