POLE2

Polymerase (DNA directed), epsilon 2, accessory subunit
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2V6Z​
Identifiers
Symbols	POLE2 ; DPE2
External IDs	OMIM: 602670 MGI: 1197514 HomoloGene: 2015 GeneCards: POLE2 Gene
EC number	2.7.7.7
Gene ontology Molecular function • DNA binding • DNA-directed DNA polymerase activity • protein binding Cellular component • nucleoplasm • epsilon DNA polymerase complex • intracellular membrane-bounded organelle Biological process • G1/S transition of mitotic cell cycle • mitotic cell cycle • telomere maintenance via recombination • telomere maintenance • DNA replication • DNA-dependent DNA replication • DNA replication initiation • DNA repair • transcription-coupled nucleotide-excision repair • nucleotide-excision repair • nucleotide-excision repair, DNA gap filling • telomere maintenance via semi-conservative replication • error-prone translesion synthesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5427	18974
Ensembl	ENSG00000100479	ENSMUSG00000020974
UniProt	P56282	O54956
RefSeq (mRNA)	NM_001197330	NM_011133
RefSeq (protein)	NP_001184259	NP_035263
Location (UCSC)	Chr 14: 49.64 – 49.69 Mb	Chr 12: 69.2 – 69.23 Mb
PubMed search

DNA polymerase epsilon subunit 2 is an enzyme that in humans is encoded by the POLE2 gene.^[1][2][3]

Interactions

POLE2 has been shown to interact with SAP18.^[4]

References

1. Li Y, Asahara H, Patel VS, Zhou S, Linn S (Jan 1998). "Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon". J Biol Chem 272 (51): 32337–44. doi:10.1074/jbc.272.51.32337. PMID 9405441.
2. Jokela M, Mäkiniemi M, Lehtonen S, Szpirer C, Hellman U, Syväoja JE (Mar 1998). "The small subunits of human and mouse DNA polymerase epsilon are homologous to the second largest subunit of the yeast Saccharomyces cerevisiae DNA polymerase epsilon". Nucleic Acids Res 26 (3): 730–4. doi:10.1093/nar/26.3.730. PMC 147316. PMID 9443964.
3. "Entrez Gene: POLE2 polymerase (DNA directed), epsilon 2 (p59 subunit)".
4. Wada M, Miyazawa H, Wang RS, Mizuno T, Sato A, Asashima M, Hanaoka F (Mar 2002). "The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA". J. Biochem. 131 (3): 307–11. doi:10.1093/oxfordjournals.jbchem.a003104. PMID 11872158.

Further reading

• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
• Post SM, Tomkinson AE, Lee EY (2003). "The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase ε". Nucleic Acids Res. 31 (19): 5568–75. doi:10.1093/nar/gkg765. PMC 206465. PMID 14500819.
• Wada M, Miyazawa H, Wang RS, Mizuno T, Sato A, Asashima M, Hanaoka F (2002). "The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA". J. Biochem. 131 (3): 307–11. doi:10.1093/oxfordjournals.jbchem.a003104. PMID 11872158.
• Huang D, Jokela M, Tuusa J, Skog S, Poikonen K, Syväoja JE (2001). "E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase ɛ B-subunit gene POLE2". Nucleic Acids Res. 29 (13): 2810–21. doi:10.1093/nar/29.13.2810. PMC 55767. PMID 11433027.
• Li Y, Pursell ZF, Linn S (2000). "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon". J. Biol. Chem. 275 (30): 23247–52. doi:10.1074/jbc.M002548200. PMID 10801849.