POLD4

Polymerase (DNA-directed), delta 4, accessory subunit
Identifiers
Symbols	POLD4 ; POLDS; p12
External IDs	OMIM: 611525 MGI: 1916995 HomoloGene: 10909 ChEMBL: 2168 GeneCards: POLD4 Gene
Gene ontology Molecular function • DNA-directed DNA polymerase activity • protein binding Cellular component • nucleus • nucleoplasm • delta DNA polymerase complex Biological process • mitotic cell cycle • telomere maintenance via recombination • telomere maintenance • DNA synthesis involved in DNA repair • DNA replication • DNA-dependent DNA replication • DNA strand elongation involved in DNA replication • DNA repair • transcription-coupled nucleotide-excision repair • base-excision repair • nucleotide-excision repair • nucleotide-excision repair, DNA gap filling • mismatch repair • translesion synthesis • telomere maintenance via semi-conservative replication • DNA damage response, detection of DNA damage Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57804	69745
Ensembl	ENSG00000175482	ENSMUSG00000024854
UniProt	Q9HCU8	Q9CWP8
RefSeq (mRNA)	NM_001256870	NM_027196
RefSeq (protein)	NP_001243799	NP_081472
Location (UCSC)	Chr 11: 67.35 – 67.36 Mb	Chr 19: 4.23 – 4.23 Mb
PubMed search

DNA polymerase delta subunit 4, also known as DNA polymerase delta subunit p12, is a protein that in humans is encoded by the POLD4 gene.^[1] It is a component of the DNA polymerase delta complex.

References

1. "Entrez Gene: polymerase (DNA-directed)".

Further reading

• Xie B, Mazloum N, Liu L, et al. (2002). "Reconstitution and characterization of the human DNA polymerase delta four-subunit holoenzyme.". Biochemistry 41 (44): 13133–42. doi:10.1021/bi0262707. PMID 12403614.
• Selak N, Bachrati CZ, Shevelev I, et al. (2008). "The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta.". Nucleic Acids Res. 36 (16): 5166–79. doi:10.1093/nar/gkn498. PMC 2532730. PMID 18682526.
• Bae SH, Bae KH, Kim JA, Seo YS (2001). "RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes.". Nature 412 (6845): 456–61. doi:10.1038/35086609. PMID 11473323.
• Matsumoto Y, Kim K, Hurwitz J, et al. (1999). "Reconstitution of proliferating cell nuclear antigen-dependent repair of apurinic/apyrimidinic sites with purified human proteins.". J. Biol. Chem. 274 (47): 33703–8. doi:10.1074/jbc.274.47.33703. PMID 10559261.
• Liu G, Warbrick E (2006). "The p66 and p12 subunits of DNA polymerase delta are modified by ubiquitin and ubiquitin-like proteins.". Biochem. Biophys. Res. Commun. 349 (1): 360–6. doi:10.1016/j.bbrc.2006.08.049. PMID 16934752.
• Tsurimoto T, Shinozaki A, Yano M, et al. (2005). "Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta.". Genes Cells 10 (1): 13–22. doi:10.1111/j.1365-2443.2004.00812.x. PMID 15670210.
• Wood RD, Shivji MK (1997). "Which DNA polymerases are used for DNA-repair in eukaryotes?". Carcinogenesis 18 (4): 605–10. doi:10.1093/carcin/18.4.605. PMID 9111189.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Huang QM, Akashi T, Masuda Y, et al. (2010). "Roles of POLD4, smallest subunit of DNA polymerase delta, in nuclear structures and genomic stability of human cells.". Biochem. Biophys. Res. Commun. 391 (1): 542–6. doi:10.1016/j.bbrc.2009.11.094. PMID 19931513.
• Li H, Xie B, Zhou Y, et al. (2006). "Functional roles of p12, the fourth subunit of human DNA polymerase delta.". J. Biol. Chem. 281 (21): 14748–55. doi:10.1074/jbc.M600322200. PMID 16510448.
• Liu L, Mo J, Rodriguez-Belmonte EM, Lee MY (2000). "Identification of a fourth subunit of mammalian DNA polymerase delta.". J. Biol. Chem. 275 (25): 18739–44. doi:10.1074/jbc.M001217200. PMID 10751307.