POLD2

Polymerase (DNA directed), delta 2, accessory subunit
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3E0J​
Identifiers
Symbol	POLD2
External IDs	OMIM: 600815 MGI: 1097163 HomoloGene: 4538 ChEMBL: 2763 GeneCards: POLD2 Gene
EC number	2.7.7.7
Gene ontology Molecular function • DNA binding • DNA-directed DNA polymerase activity • protein binding Cellular component • nucleus • nucleoplasm Biological process • mitotic cell cycle • telomere maintenance via recombination • telomere maintenance • DNA replication • DNA strand elongation involved in DNA replication • DNA repair • transcription-coupled nucleotide-excision repair • base-excision repair • nucleotide-excision repair • nucleotide-excision repair, DNA gap filling • mismatch repair • translesion synthesis • telomere maintenance via semi-conservative replication • DNA damage response, detection of DNA damage Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5425	18972
Ensembl	ENSG00000106628	ENSMUSG00000020471
UniProt	P49005	O35654
RefSeq (mRNA)	NM_001127218	NM_008894
RefSeq (protein)	NP_001120690	NP_032920
Location (UCSC)	Chr 7: 44.11 – 44.12 Mb	Chr 11: 5.87 – 5.88 Mb
PubMed search

DNA polymerase delta subunit 2 is an enzyme that in humans is encoded by the POLD2 gene.^[1][2] It is a component of the DNA polymerase delta complex.

Interactions

POLD2 has been shown to interact with PCNA.^[3]

References

1. Zhang J, Tan CK, McMullen B, Downey KM, So AG (Feb 1996). "Cloning of the cDNAs for the small subunits of bovine and human DNA polymerase delta and chromosomal location of the human gene (POLD2)". Genomics 29 (1): 179–86. doi:10.1006/geno.1995.1229. PMID 8530069.
2. "Entrez Gene: POLD2 polymerase (DNA directed), delta 2, regulatory subunit 50kDa".
3. Lu, Xiaoqing; Tan Cheng-Keat; Zhou Jin-Qiu; You Min; Carastro L Michael; Downey Kathleen M; So Antero G (Jul 2002). "Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta". J. Biol. Chem. (United States) 277 (27): 24340–5. doi:10.1074/jbc.M200065200. ISSN 0021-9258. PMID 11986310.

Further reading

• Hindges R, Hübscher U (1997). "Cloning, chromosomal localization, and interspecies interaction of mouse DNA polymerase delta small subunit (PolD2).". Genomics 44 (1): 45–51. doi:10.1006/geno.1997.4838. PMID 9286699.
• Hisama FM, Chen YH, Meyn MS, et al. (2000). "WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts". Cancer Res. 60 (9): 2372–6. PMID 10811112.
• Mo J, Liu L, Leon A, et al. (2000). "Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA". Biochemistry 39 (24): 7245–54. doi:10.1021/bi0000871. PMID 10852724.
• Perez A, Leon A, Lee MY (2000). "Characterization of the 5'-flanking region of the gene encoding the 50 kDa subunit of human DNA polymerase delta". Biochim. Biophys. Acta 1493 (1–2): 231–6. doi:10.1016/s0167-4781(00)00153-6. PMID 10978529.
• Szekely AM, Chen YH, Zhang C, et al. (2000). "Werner protein recruits DNA polymerase δ to the nucleolus". Proc. Natl. Acad. Sci. U.S.A. 97 (21): 11365–70. doi:10.1073/pnas.97.21.11365. PMC 17206. PMID 11027336.
• He H, Tan CK, Downey KM, So AG (2001). "A tumor necrosis factor α- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase δ and proliferating cell nuclear antigen". Proc. Natl. Acad. Sci. U.S.A. 98 (21): 11979–84. doi:10.1073/pnas.221452098. PMC 59753. PMID 11593007.
• Lu X, Tan CK, Zhou JQ, et al. (2002). "Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta". J. Biol. Chem. 277 (27): 24340–5. doi:10.1074/jbc.M200065200. PMID 11986310.
• Ohta S, Shiomi Y, Sugimoto K, et al. (2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". J. Biol. Chem. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Liu L, Rodriguez-Belmonte EM, Mazloum N, et al. (2003). "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen". J. Biol. Chem. 278 (12): 10041–7. doi:10.1074/jbc.M208694200. PMID 12522211.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Tsurimoto T, Shinozaki A, Yano M, et al. (2005). "Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta". Genes Cells 10 (1): 13–22. doi:10.1111/j.1365-2443.2004.00812.x. PMID 15670210.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.