Interleukin-18 receptor

interleukin 18 receptor 1
Identifiers
Symbol	IL18R1
Alt. symbols	IL1RRP, IL-1Rrp, CD218a
Entrez	8809
HUGO	5988
OMIM	604494
RefSeq	NM_003855
UniProt	Q13478
Other data
Locus	Chr. 2 q12

interleukin 18 receptor accessory protein
Identifiers
Symbol	IL18RAP
Alt. symbols	AcPL, CD218b
Entrez	8807
HUGO	5989
OMIM	604509
RefSeq	NM_003853
UniProt	O95256
Other data
Locus	Chr. 2 p24.3-24.1

The interleukin-18 receptor (IL-18R) is an interleukin receptor of the immunoglobulin superfamily.^[1][2] IL-18R is a heteromeric complex of alpha- and beta-chains encoded by the genes IL18R1 and IL18RAP respectively.

Endometrial IL-18 receptor mRNA and the ratio of IL-18 binding protein to interleukin 18 are significantly increased in adenomyosis patients in comparison to normal people, indicating a role in its pathogenesis.^[3]

References

1. Sergi B, Penttila I (2004). "Interleukin 18 receptor". J. Biol. Regul. Homeost. Agents 18 (1): 55–61. PMID 15323361.
2. Wu C, Sakorafas P, Miller R, McCarthy D, Scesney S, Dixon R, Ghayur T (2003). "IL-18 receptor beta-induced changes in the presentation of IL-18 binding sites affect ligand binding and signal transduction". J. Immunol. 170 (11): 5571–7. doi:10.4049/jimmunol.170.11.5571. PMID 12759435.
3. Huang, H.; Yu, H.; Chan, S.; Lee, C.; Wang, H.; Soong, Y. (2010). "Eutopic endometrial interleukin-18 system mRNA and protein expression at the level of endometrial-myometrial interface in adenomyosis patients". Fertility and Sterility 94 (1): 33–39. doi:10.1016/j.fertnstert.2009.01.132. PMID 19394601.

External links

• Receptors, Interleukin-18 at the US National Library of Medicine Medical Subject Headings (MeSH)