WY-46824
 | |
| Systematic (IUPAC) name | |
|---|---|
|
1-[1-(3-chlorophenyl)-2-(4-methylpiperazin-1-yl)ethyl]cyclohexan-1-ol | |
| Identifiers | |
| PubChem | CID 10314993 |
| ChemSpider | 8490458 |
| ChEMBL | CHEMBL511347 |
| Chemical data | |
| Formula | C19H29ClN2O |
| Molar mass | 336.89936 g/mol |
| |
| |
WY-46824 is a norepinephrine-dopamine reuptake inhibitor that was disclosed by Paige Mahaney, et al. of Wyeth in 2008.[1] The compound actually appears in an article a year earlier in 2007 but is not the main focus of the work.[2] These are the only two citations that can be found for it on PubMed. It has been patented but presumably within the framework of it being an analog of venlafaxine.[3]
It has NET binding of 46 nM, DAT = 58 nM and SERT = 18795 nM. The racemic compound was resolved into its constituent enantiomers.
References
- ↑ Mahaney, P.; Gavrin, L.; Trybulski, E.; Stack, G.; Vu, T.; Cohn, S.; Ye, F.; Belardi, J.; Santilli, A.; Sabatucci, J.; Leiter, J.; Johnston, G. H.; Bray, J. A.; Burroughs, K. D.; Cosmi, S. A.; Leventhal, L.; Koury, E. J.; Zhang, Y.; Mugford, C. A.; Ho, D. M.; Rosenzweig-Lipson, S. J.; Platt, B.; Smith, V. A.; Deecher, D. C. (2008). "Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors". Journal of Medicinal Chemistry 51 (13): 4038–4049. doi:10.1021/jm8002262. PMID 18557608.
- ↑ Mason, J. N.; Deecher, D. C.; Richmond, R. L.; Stack, G.; Mahaney, P. E.; Trybulski, E.; Winneker, R. C.; Blakely, R. D. (2007). "Desvenlafaxine Succinate Identifies Novel Antagonist Binding Determinants in the Human Norepinephrine Transporter". Journal of Pharmacology and Experimental Therapeutics 323 (2): 720–729. doi:10.1124/jpet.107.125716. PMID 17673606.
- ↑ U.S. Patent 4,826,844
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