Interleukin-1 receptor

interleukin 1 receptor, type I
Identifiers
Symbol	IL1R1
Alt. symbols	IL1R, IL1RA
Entrez	3554
HUGO	5993
OMIM	147810
RefSeq	NM_000877
UniProt	P14778
Other data
Locus	Chr. 2 q12

interleukin 1 receptor, type II
Identifiers
Symbol	IL1R2
Alt. symbols	IL1RB
Entrez	7850
HUGO	5994
OMIM	147811
RefSeq	NM_173343
UniProt	P27930
Other data
Locus	Chr. 2 q12

interleukin 1 receptor accessory protein
Identifiers
Symbol	IL1RAP
Alt. symbols	IL-1RAcP, IL1R3, C3orf13
Entrez	3556
HUGO	5995
OMIM	602626
RefSeq	NM_134470
UniProt	Q9NPH3
Other data
Locus	Chr. 3 q28

Interleukin-1 receptor (IL-1R) is a cytokine receptor which binds interleukin 1.^[1] Two forms of the receptor exist. The type I receptor is primarily responsible for transmitting the inflammatory effects of interleukin-1 (IL-1) while type II receptors may act as a suppressor of IL-1 activity by competing for IL-1 binding.^[1] Also opposing the effects of IL-1 is the IL-1 receptor antagonist (IL-1RA).^[2]

The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction.^[3]

References

1. Kuno K, Matsushima K (1994). "The IL-1 receptor signaling pathway" (abstract page). J. Leukoc. Biol. 56 (5): 542–7. PMID 7964161.
2. Arend WP (1991). "Interleukin 1 receptor antagonist. A new member of the interleukin 1 family". J. Clin. Invest. 88 (5): 1445–51. doi:10.1172/JCI115453. PMC 295645. PMID 1834696.
3. Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (March 1997). "The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)". J. Biol. Chem. 272 (12): 7727–31. doi:10.1074/jbc.272.12.7727. PMID 9065432.

External links

• Receptors, Interleukin-1 at the US National Library of Medicine Medical Subject Headings (MeSH)