DNA polymerase epsilon

DNA-directed DNA polymerase
Identifiers
EC number 2.7.7.7
CAS number 9012-90-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

DNA polymerase epsilon is a member of the DNA polymerase family of enzymes. It is composed of the following four subunits: POLE (central catalytic unit), POLE2 (subunit 2), POLE3 (subunit 3), and POLE4 (subunit 4). Recent evidence suggests that it plays a minor role in DNA replication, and is mostly involved in correcting errors made by DNA polymerase delta during leading strand replication.[1]

References

  1. Johnson RE, Klassen R, Prakash L, Prakash S (July 16, 2015). "A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands". Mol. Cell. 59 (2): 163–175. doi:10.1016/j.molcel.2015.05.038. PMID 26145172.


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