Signal-recognition-particle GTPase

Signal-recognition-particle GTPase (EC 3.6.5.4) is an enzyme with systematic name GTP phosphohydrolase (protein-synthesis-assisting).^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

GTP + H₂O

\rightleftharpoons

GDP + phosphate

Enzyme activity is associated with the signal-recognition particle.

References

↑ Connolly, T. and Gilmore, R. (1989). "The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide". Cell 57 (4): 599–610. doi:10.1016/0092-8674(89)90129-3. PMID 2541918.
↑ Connolly, T., Rapiejko, P.J. and Gilmore, R. (1991). "Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor". Science 252 (5009): 1171–1173. doi:10.1126/science.252.5009.1171. PMID 1851576.
↑ Miller, J.D., Wilhelm, H., Gierasch, L., Gilmore, R. and Walter, P. (1993). "GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation". Nature 366 (6453): 351–354. doi:10.1038/366351a0. PMID 8247130.
↑ Freymann, D.M., Keenan, R.J., Stroud, R.M. and Walter, P. (1997). "Structure of the conserved GTPase domain of the signal recognition particle". Nature 385 (6614): 361–364. doi:10.1038/385361a0. PMID 9002524.

External links

Signal-recognition-particle GTPase at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolases: acid anhydride hydrolases (EC 3.6)

3.6.1

3.6.2

3.6.3-4: ATPase

3.6.3

Cu++ (3.6.3.4)	Menkes/ATP7A Wilson/ATP7B

Ca+ (3.6.3.8)	SERCA ATP2A1 ATP2A2 ATP2A3 Plasma membrane ATP2B1 ATP2B2 ATP2B3 ATP2B4 SPCA ATP2C1 ATP2C2

Na+/K+ (3.6.3.9)	ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP1B4

H+/K+ (3.6.3.10)	ATP4A

Other P-type ATPase	ATP8B1 ATP10A ATP11B ATP12A ATP13A2 ATP13A3

3.6.4

3.6.5: GTPase

3.6.5.1: Heterotrimeric G protein	G_αs G_αi GNAI1 GNAI2 GNAI3 G_αq/11 GNAQ GNA11 G_α12/13 GNA12 GNA13 Transducin GNAT1 GNAT2

3.6.5.2: Small GTPase > Ras superfamily	Rho family of GTPases: Cdc42 CDC42 TC10 TCL RhoUV RhoU RhoV Rac Rac1 2 3 RhoG RhoBTB 1 2 RhoH Rho A B C Rnd 1 2 3 RhoDF RhoF RhoD other: Ras HRAS KRAS NRAS Rab RAB23 RAB27 Arf ARF6 SAR1B ARL13B ARL6 Ran Rheb Rap RGK

3.6.5.3: Protein-synthesizing GTPase	Prokaryotic IF-2 EF-Tu EF-G Eukaryotic

3.6.5.5-6: Polymerization motors	Dynamin Tubulin

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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Signal-recognition-particle GTPase

References

See also

External links