UDP-2,3-diacylglucosamine diphosphatase

UDP-2,3-diacylglucosamine diphosphatase
Identifiers
EC number 3.6.1.54
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

UDP-2,3-diacylglucosamine diphosphatase (EC 3.6.1.54, UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine pyrophosphatase, ybbF (gene), lpxH (gene)) is an enzyme with systematic name UDP-2,3-bis((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine 2,3-bis((3R)-3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate phosphohydrolase.[1][2] This enzyme catalyses the following chemical reaction

UDP-2,3-bis[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + H2O \rightleftharpoons 2,3-bis[(3R)-3-hydroxymyristoyl]-beta-D-glucosaminyl 1-phosphate + UMP

The enzyme catalyses a step in the biosynthesis of lipid A.

References

  1. Babinski, K.J., Ribeiro, A.A. and Raetz, C.R. (2002). "The Escherichia coli gene encoding the UDP-2,3-diacylglucosamine pyrophosphatase of lipid A biosynthesis". J. Biol. Chem. 277: 25937–25946. doi:10.1074/jbc.m204067200. PMID 12000770.
  2. Babinski, K.J., Kanjilal, S.J. and Raetz, C.R. (2002). "Accumulation of the lipid A precursor UDP-2,3-diacylglucosamine in an Escherichia coli mutant lacking the lpxH gene". J. Biol. Chem. 277: 25947–25956. doi:10.1074/jbc.m204068200. PMID 12000771.

External links

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