UDP-2,3-diacylglucosamine diphosphatase
UDP-2,3-diacylglucosamine diphosphatase (EC 3.6.1.54, UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine pyrophosphatase, ybbF (gene), lpxH (gene)) is an enzyme with systematic name UDP-2,3-bis((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine 2,3-bis((3R)-3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate phosphohydrolase.[1][2] This enzyme catalyses the following chemical reaction
- UDP-2,3-bis[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + H2O
2,3-bis[(3R)-3-hydroxymyristoyl]-beta-D-glucosaminyl 1-phosphate + UMP
The enzyme catalyses a step in the biosynthesis of lipid A.
References
- ↑ Babinski, K.J., Ribeiro, A.A. and Raetz, C.R. (2002). "The Escherichia coli gene encoding the UDP-2,3-diacylglucosamine pyrophosphatase of lipid A biosynthesis". J. Biol. Chem. 277: 25937–25946. doi:10.1074/jbc.m204067200. PMID 12000770.
- ↑ Babinski, K.J., Kanjilal, S.J. and Raetz, C.R. (2002). "Accumulation of the lipid A precursor UDP-2,3-diacylglucosamine in an Escherichia coli mutant lacking the lpxH gene". J. Biol. Chem. 277: 25947–25956. doi:10.1074/jbc.m204068200. PMID 12000771.
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